MRE11A

Double-strand break repair protein MRE11A is a protein that in humans is encoded by the MRE11A gene.

Function

This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Orthologs of MRE11A

Mre11, an ortholog of human MRE11A, occurs in the prokaryote archaeon Sulfolobus acidocaldarius. In this organism the Mre11 protein interacts with the Rad50 protein and appears to have an active role in the repair of DNA damages experimentally introduced by gamma radiation. Similarly, during meiosis in the eukaryotic protist Tetrahymena Mre11 is required for repair of DNA damages, in this case double-strand breaks, by a process that likely involves homologous recombination. These observations suggest that human MRE11A is descended from prokaryotic and protist ancestral Mre11 proteins that served a role in early processes for repairing DNA damage.

Meal, Ready-to-Eat

The Meal, Ready-to-Eat – commonly known as the MRE – is a self-contained, individual field ration in lightweight packaging bought by the United States military for its service members for use in combat or other field conditions where organized food facilities are not available. The MRE replaced the canned MCI, or Meal, Combat, Individual rations, in 1981, and is the intended successor to the lighter LRP ration developed by the United States Army for Special Forces and Ranger patrol units in Vietnam.

History

The first soldier ration established by a Congressional Resolution, during the Revolutionary War, consisted of enough food to feed a man for one day, mostly beef, peas, and rice. During the Civil War, the military moved toward canned goods. Later, self-contained kits were issued as a whole ration and contained canned meat, pork, bread, coffee, sugar and salt. During the First World War, canned meats were replaced with lightweight preserved meats (salted or dried) to save weight and allow more rations to be carried by soldiers carrying their supplies on foot. At the beginning of World War II, a number of new field rations were introduced, including the Mountain ration and the Jungle ration. However, cost-cutting measures by Quartermaster Command officials during the latter part of World War II and the Korean War again saw the predominance of heavy canned C rations issued to troops, regardless of operating environment or mission. The use of canned wet rations continued through the Vietnam War, with the improved MCI field ration.

Wave

In physics, a wave is an oscillation accompanied by a transfer of energy that travels through space or mass. Frequency refers to the addition of time. Wave motion transfers energy from one point to another, which displace particles of the transmission medium—that is, with little or no associated mass transport. Waves consist, instead, of oscillations or vibrations (of a physical quantity), around almost fixed locations.

There are two main types of waves. Mechanical waves propagate through a medium, and the substance of this medium is deformed. The deformation reverses itself owing to restoring forces resulting from its deformation. For example, sound waves propagate via air molecules colliding with their neighbors. When air molecules collide, they also bounce away from each other (a restoring force). This keeps the molecules from continuing to travel in the direction of the wave.

The second main type of wave, electromagnetic waves, do not require a medium. Instead, they consist of periodic oscillations of electrical and magnetic fields originally generated by charged particles, and can therefore travel through a vacuum. These types of waves vary in wavelength, and include radio waves, microwaves, infrared radiation, visible light, ultraviolet radiation, X-rays, and gamma rays.

Park West, Dublin

Park West (Irish: Páirc an Iarthair) is a large business campus within greater Ballyfermot, notably Cherry Orchard, Dublin, Ireland, with some residential development.

There are over 300 companies with 10,000 employees.

Location and content

Located just inside the M50 orbital motorway in west Dublin, the development comprises several million square metres of office and retail space, along with an Aspect hotel, a private hospital, and three apartment complexes.

Park West is in the administration of Dublin City Council, and Dublin postal districts Dublin 10 and Dublin 12, chiefly the latter.

Art

Park West is home to Europe's tallest wind and water mobile sculpture, Wave by Angela Conner. It is a 39.3 metre (129 feet) tall sculpture made of polystyrene covered with layers of carbon resin. It is fixed into a 7.6 metre (25 foot) pit filed with 9.5 tonnes of lead.

Transport

The campus is accessible by road (primarily the (New) Nangor Road, as well as Killeen Road and Cloverhill), bus (routes 79A and 151) and rail at the Park West and Cherry Orchard railway station. At a moderate distance to the south is the Kylemore stop on the Luas red line.

Wave (Antonio Carlos Jobim album)

Wave is the third album by Antônio Carlos Jobim, released in 1967 on A&M Records. It is known as Jobim's most successful album to date (# 5 US JAZZ ALBUMS 1967,# 114 US ALBUMS 1968), and it was listed by Rolling Stone Brazil as one of the 100 best Brazilian albums in history.

Track listing

Personnel

Strings