Warning is a 2013 Hindi thriller 3D film directed by Gurmmeet Singh and produced by Anubhav Sinha and Jitendra Jain. The film was released on 27 September 2013 and features Santosh Barmola, Suzana Rodrigues and Manjari Fadnis as main characters.
The film is a remake of the 2006 film Open Water 2: Adrift
Warning was a French hard-rock band active from 1980 until 1985. They released three albums sung in French language, their second being produced by Dieter Dierks.
Warning were a UK-based doom metal band.
Warning flagged the rise of post-2000 wave of traditional doom metal. They were formed by Patrick Walker and drummer Stuart Springthorpe in 1994 in Harlow, Essex. The band is notable for its down-tempo, progressive, melodic and heavy doom-laden sound; the idiosyncratic and poignant vocals of Patrick Walker; and his introspective, darkly-confessional lyrical themes.
The band released two demo tapes, Revelation Looms in Feb 1996 and Blessed By Sabbath in March 1997 which led them to gain underground metal press attention and label interest.
Warning debuted 1999 with The Strength To Dream on Rich Walker's Miskatonic Foundation label. With this album, Warning gained a cult status within doom metal circles, but they soon disbanded after their 2001 European tour with Jack Frost. They regrouped in 2004 to write new songs and to perform at The Doom Shall Rise festival in Germany in 2005, and released second album Watching From A Distance in 2006 to wide acclaim.
An immune receptor (or immunologic receptor) is a receptor, usually on a cell membrane, which binds to a substance (for example, a cytokine) and causes a response in the immune system.
The main receptors in the immune system are pattern recognition receptors (PRRs), Toll-like receptors (TLRs), killer activated and killer inhibitor receptors (KARs and KIRs), complement receptors, Fc receptors, B cell receptors and T cell receptors.
The alpha-1 (α1) adrenergic receptor is a G protein-coupled receptor (GPCR) associated with the Gq heterotrimeric G-protein. It consists of three highly homologous subtypes, including α1A-, α1B-, and α1D-adrenergic. Catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) signal through the α1-adrenergic receptor in the central and peripheral nervous systems.
The α1-adrenergic receptor has several general functions in common with the α2-adrenergic receptor, but also has specific effects of its own. α1-receptors primarily mediate smooth muscle contraction, but have important functions elsewhere as well. The neurotransmitter noradrenaline has higher affinity for the α1 receptor than does adrenaline (which is a hormone).
In smooth muscle cells of blood vessels the principal effect of activation of these receptors is vasoconstriction. Blood vessels with α1-adrenergic receptors are present in the skin, the sphincters of gastrointestinal system, kidney (renal artery) and brain. During the fight-or-flight response vasoconstriction results in decreased blood flow to these organs. This accounts for the pale appearance of the skin of an individual when frightened.
R10 can refer to:
and also :