Wapello may refer to:
Wapello (1787–1842) was a Native American chief of the Meskwaki tribe.
Wapello was born in 1787 at Prairie du Chien, Northwest Territory, in what is now the state of Wisconsin. Short and stout in physical stature, with a kindly visage, Wapello entertained friendly relations with white settlers throughout his life. Under pressure to cede territory to the United States, he signed peace treaties with them at Fort Armstrong at Rock Island, Illinois, on 3 September 1822; at Prairie du Chien on 15 July 1830; at Fort Armstrong on 21 September 1832; at Dubuque, Iowa, on 28 September 1836; and at Washington, D.C., on 21 October 1837. During the Black Hawk War, Wapello supported chief Keokuk. In the 1840s, many Fox were forced west to Kansas.
In 1829, he led his tribe to Muscatine Slough on the west bank of the Mississippi River and later settled in Iowa. The frontier town of Wapello later developed near here. In 1837, he accompanied the renowned chief Keokuk and United States Indian agent General Joseph M. Street on a tour of northeastern and mid-Atlantic states. During this trip, Wapello made an eloquent speech at Boston, Massachusetts, wherein he expressed friendly sentiments towards white settlers and reaffirmed his desire to continue harmonious relations with them.