Proposed top-level domain

The Domain Name System of the Internet consists of a set of top-level domains which constitute the root domain of the hierarchical name space and database. In the growth of the Internet, it became desirable to expand the set of initially six generic top-level domains in 1984. As a result new top-level domain names have been proposed for implementation by ICANN. Such proposals included a variety of models ranging from adoption of policies for unrestricted gTLDs that could be registered by anyone for any purpose, to chartered gTLDs for specialized uses by specialized organizations. In October 2000, ICANN published a list of proposals for top-level domain strings it had received.

Geographic proposals

MED28

Mediator of RNA polymerase II transcription subunit 28 is an enzyme that in humans is encoded by the MED28 gene. It forms part of the Mediator complex.

Function

Subunit Med28 of the Mediator may function as a scaffolding protein within Mediator by maintaining the stability of a submodule within the head module, and components of this submodule act together in a gene-regulatory programme to suppress smooth muscle cell differentiation. Thus, mammalian Mediator subunit Med28 functions as a repressor of smooth muscle-cell differentiation, which could have implications for disorders associated with abnormalities in smooth muscle cell growth and differentiation, including atherosclerosis, asthma, hypertension, and smooth muscle tumours.

Interactions

MED28 has been shown to interact with Merlin,Grb2 and MED26.

See also

References

This article incorporates text from the public domain Pfam and InterPro IPR021640

Further reading

MED6

Mediator of RNA polymerase II transcription subunit 6 is one of the subunits of the Mediator complex. It is an enzyme that in humans is encoded by the MED6 gene.

Protein family

This family of proteins represent the transcriptional mediator protein subunit 6 that is required for activation of many RNA polymerase II promoters and which are conserved from yeast to humans.

Interactions

MED6 has been shown to interact with:

References

Further reading

External links

This article incorporates text from the public domain Pfam and InterPro IPR007018

Sheepshead (game)

Sheepshead or Sheephead is a trick-taking card game related to the Skat family of games. It is the Americanized version of a card game that originated in Central Europe in the late 18th century under the German name Schafkopf. Sheepshead is most commonly played by five players, but variants exist to allow for two to eight players. There are also many other variants to the game rules, and many slang terms used with the game.

Although Schafkopf literally means "sheepshead," it has nothing to do with sheep; the term probably was derived and translated incorrectly from Middle High German and referred to playing cards on a barrel head (from kopf, meaning head, and Schaff, meaning a barrel).

In the United States, sheepshead is most commonly played in Wisconsin as well as the German counties in Southern Indiana, which has large German-American populations, and on the internet. Numerous tournaments are held throughout Wisconsin during the year, with the largest tournament being the "Nationals", held annually in the Wisconsin Dells during a weekend in September, October or November, and mini-tournaments held hourly throughout Germanfest in Milwaukee during the last weekend of each July.

WALK (AM)

WALK (1370 AM) is a radio station licensed to Patchogue, New York. The station's first broadcast was on Sunday April 20, 1952 from the infamous 'fish-bowl' studios on Colonial Drive in East Patchogue. The station's studios would remain there for more than 62 years until they were sold to current owner Connoisseur Media. The station broadcasts an adult standards format, simulcasting WHLI 1100 AM Hempstead, New York.

See also

References

External links