WWTR1
WW domain-containing transcription regulator protein 1 is a protein that in humans is encoded by the WWTR1 gene.
Function
WWTR1 It is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/LATS2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADs and has a key role in coupling them to the transcriptional machinery such as the mediator complex.
Using the human SHSY5Y cell line as a model of neuronal differentiation, human FAT1 was shown to regulate the nucleocytoplasmic relocation of WWTR1/TAZ and enhanced transcription of the Hippo target gene CTGF. The same study also showed FAT1 was able to regulate TGF-beta signalling
WWTR
WWTR (1170 AM, "EBC Radio") is a radio station in Bridgewater, New Jersey broadcasting a South Asian-oriented ethnic format. The station is currently owned by EBC Music, Inc.
History
The station signed on December 23, 1971 as WBRW, a middle of the road-formatted station owned by the Somerset Valley Broadcasting Corporation and licensed to Somerville, New Jersey. The station subsequently shifted to an adult contemporary format, and was later relicensed to Bridgewater. However, WBRW began to lose money during the 1980s, and in 1990 it was taken off-the-air.
The Bridgewater Broadcasting Corporation purchased the license in 1993, and brought WBRW back on the air in 1996. Initially airing its own programming, in December 1997 the station became WSPW and began to simulcast One on One Sports programming from WJWR in Newark (now WSNR in Jersey City). The following year, the station was sold to New Jersey Broadcasters and in April 1999 became a simulcast of sister standards station WMTR, under the callsign WWTR. New Jersey Broadcasting was sold to Greater Media in 2001. WMTR and WWTR shifted to a classic oldies format, emphasizing pre-1964 music, in 2004.
