The station began operations on February 15, 1950 with the call sign WSYR-TV. It was owned by Advance Publications (the Newhouse family's company) along with the Syracuse Post-Standard, Syracuse Herald-Journal, and WSYR radio (AM 570 and FM 94.5, now WYYY). It was Syracuse's second television station, signing on a year and three months after WHEN-TV (now WTVH). It originally had facilities at the Kemper Building in Downtown Syracuse. In 1958, WSYR-AM-FM-TV moved to new studios on James Street.