WHSC2
Negative elongation factor A is a protein that in humans is encoded by the WHSC2 gene.
Function
This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation. WHSC2 encodes the NELF-A subunit of the NELF complex.
Interactions
Podcasts:
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Ballad Of Richard K
by: AsgKeep down by the ones who sat by your side
Guts blushing on a night shadow lonley pize
In the house with no home, cut to size
Hoplessly divided
I bent down into the knife
In the path of my foes, left to die
Visions of the highway
I bent back into the light
Well your god won't smile
And your conscience can't sleep
Someone in the wind as fire flies
against your sheild
What if i killed you all
Would it build me up
Someone in the wind as fire flies
Against your sheild
Ten seconds till the blackout parts with his crime
Got money don't buy in, dont buy the light
In the house with no home, cut to size
Hoplessly divided
I bent down into the knife
Well your god won't smile
And your conscience can't sleep
Someone in the wind as fire flies
Against your sheild
What if i killed you all
Would it build me up
Someone in the wind as fire flies
Against your sheild
Lay down, got rythem
Where trying to find it
On stage like a luminous gunner
Where trying to find it
Well your god won't smile
And your conscience can' sleep
Someone in the wind as fire flies
Against your sheild
What if i killed you all
Would it build me up
Someone in the wind as fire flies