WHSC1

Probable histone-lysine N-methyltransferase NSD2 is an enzyme that in humans is encoded by the WHSC1 gene.

This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences.

References

Further reading

WHSC2

Negative elongation factor A is a protein that in humans is encoded by the WHSC2 gene.

Function

This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation. WHSC2 encodes the NELF-A subunit of the NELF complex.

Interactions

WHSC

WHSC is a sports talk radio station in Myrtle Beach, South Carolina.

It is the flagship radio station of the Myrtle Beach Pelicans, who play in the Carolina League of Minor League Baseball as the Advanced-A affiliate of the Texas Rangers.

History

WHSC originally signed on as WJAL in 1977 in Conway, South Carolina. A few years later the call sign became WJXY, a call sign that stayed with the station for many years. WJXY, at one time, was a daytime-only Country music station in the 1970s. An FM frequency at 93.9 was added around 1990, at which time the AM switched to Southern gospel. In 1995, the format changed to adult standards, with most of the music coming from the AM Only satellite format. By this time the station had a limited nighttime signal.

In Fall 1999, Hurricane Floyd damaged WJXY's studios and transmitter site and forced WJXY-FM, WXJY and WSEA to move to the WSYN/WDAI studios near Inlet Square Mall. At the time WJXY aired Conway High School football; those games moved to WRNN-FM. WJXY was off the air for several months. Early in 2000, the station was back, but not in stereo. Many listeners had complained.