Vortioxetine
Vortioxetine (vor-tye-OKS-e-teen, trade name Brintellix (BRIN-tel-ix) and Trintellix in Canada) is an atypical antidepressant (a serotonin modulator and stimulator) made by Lundbeck and Takeda.
Medical use
Vortioxetine is used as first-line treatment for major depressive disorder.
Side effects
The most common side effects reported with vortioxetine are nausea, diarrhea, dry mouth, constipation, vomiting, flatulence, dizziness, and sexual dysfunction. Vortioxetine used alone in high dose or in combination with other medications, such as other antidepressants, can produce a potentially life-threatening drug reaction known as serotonin syndrome.
Incidence of sexual dysfunction is reportedly higher in patients taking vortioxetine than in people taking placebos but appears to be lower than in people taking other antidepressants
Pharmacodynamics
Vortioxetine is a so-called "serotonin modulator and stimulator".<ref name="urlLundbeck's "Serotonin Modulator and Stimulator" Lu AA21004: How Novel? How Good? - GLG News">"Lundbeck's "Serotonin Modulator and Stimulator" Lu AA21004: How Novel? How Good? - GLG News". </ref> It has been shown to possess the following pharmacological actions:
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