Calcitriol receptor
The calcitriol receptor, also known as the vitamin D receptor (VDR) and also known as NR1I1 (nuclear receptor subfamily 1, group I, member 1), is a member of the nuclear receptor family of transcription factors. Upon activation by vitamin D, the VDR forms a heterodimer with the retinoid-X receptor and binds to hormone response elements on DNA resulting in expression or transrepression of specific geneproducts. The VDR not only regulates transcriptional responses but also involved in microRNA-directed post transcriptional mechanisms. In humans, the vitamin D receptor is encoded by the VDR gene.
Glucocorticoids are known to decrease expression of VDR, which is expressed in most tissues of the body and regulate intestinal transport of calcium, Iron and other minerals.
Function
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows similarity of sequence to the steroid and thyroid hormone receptors.
Podcasts:
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by D-stroy
Vitamin D
by: D-stroyintroducing the nigga that be boosting
he brought the band he brought the orchestra
the people would like to know.....
[Verse One]
WHY THEY CALL YOU
D-STROY?? cause i'm known for shucking fit up
snuffing the cut funky like the stuff in ya but
enough with corrupt rhyme's and the voice drum's hunted
get confronted for one hundred you bum's fronted
redundant dumb shit you submit made stock's plument
i knot stomach's with def lepoard's arm and drumsets
my lung's swung it lyric's ain't done blunted
or drunk shit which one of you crumb's WANT IT
this natural shits imaculate layback and sit
accurate for battle's quick if you flap ya lip
when i rap you quit acting slick pack and split
or i'll get at you quick like attacking pit's (DOGS)
you'll get thrown from a balcony in london
will be bloody lonesome "IT'S A HOMERUN"
In a zone crumb final score i keep vinyl raw
extra strength tylenol for dinosaur
lion's rah nominee's fond of dee honor me
with novelty bring out the dead and set zombie's free (BRAIN'S)
power's for austin rugged like clothes on orphans
richard dawson survey says this kid is awesome
[Chorus]
Vitamin D.s.t.r.o.y.
take 2 in the morning you'll be saying oh my
get up feeling great for real's no lie
dont knock it till you go try it's alright
[Singing]
so fresh i wanna be
so fresh a hip hop star
so fresh i wanna to rock's
so fresh show's near or far
I love to blow up spot's all day
i need you to rock this way
D.s.t.r.o.y....Oooo.yyyy.
D.s.t.r.o.y...Oooo.yyyy.
Oooyyyyy
[Verse Two]
i do damage daily to scare rebel's duplicator's dare devil's
dead dentals of dudes that are 1 dimentional
melts metal's with snare treble's bass at decibel
higher then air level's on point like a decimal
dynamic devine how im defined
demands dummies decline deactivate design
REWIND ya decomposed and diagnosed as decayed
deemed deadly by d.j.'s your careers delayed
so dangerous so dangerous
down the ditch on the double every stranger dip
no debating with D-stroy's dictatorship
have dude's shook like that final destinations flick
concerto of a desparado
i do damage dialy to my bad i did that befo
decapitate all derelects with dialect that's definite.
my duties dominance over degenerates with deficit
document in my dairy i diehard with drop kick
the undisputed D dastardly's diabolic
don't get it distorted I deflect defects to no degree.
"YO DUN DUN" im done so take to of ya