Virodhamine
Virodhamine (O-arachidonoyl ethanolamine; O-AEA) is an endocannabinoid and a nonclassic eicosanoid, derived from arachidonic acid. O-Arachidonoyl ethanolamine is arachidonic acid and ethanolamine joined by an ester linkage, the opposite of the amide linkage found in anandamide. Based on this opposite orientation, the molecule was named virodhamine from the Sanskrit word virodha, which means opposition. It acts as an antagonist of the CB1 receptor and agonist of the CB2 receptor. Concentrations of virodhamine in the human hippocampus are similar to those of anandamide, but they are 2- to 9-fold higher in peripheral tissues that express CB2. Virodhamine lowers body temperature in mice, demonstrating cannabinoid activity in vivo.
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Podcasts:
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by The Creatures
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by Uncle Slam
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by Creatures
Fruitman
by: The CreaturesOld man sits in an apricot tree
He sees I and I sees he
Old man sweet as the fruit he's picking
Knows the rhythm of nature's ticking
Gives a smile of tooth and metal
Winks an eye like a falling petal
Face a furrowed field of life tracks
The years of the living knife
He I love, he I know
Seasons come, so fruitman go Through the crowd I enter in
See the head of virgin skin
Frail the old man's hand I take
Peace be with you Sunday shake
Sweet old man he turns to me
Tries to tell me what's to be
He don't say no words at all
Tears from him like fruit do fall
He I love, he I know
See sons that come, so fruitman go