Rofecoxib

Rofecoxib /ˌrɒfˈkɒksɪb/ is a nonsteroidal anti-inflammatory drug (NSAID) that has now been withdrawn over safety concerns. It was marketed by Merck & Co. to treat osteoarthritis, acute pain conditions, and dysmenorrhea. Rofecoxib was approved by the U.S. Food and Drug Administration (FDA) on May 20, 1999, and was marketed under the brand names Vioxx, Ceoxx, and Ceeoxx.

Rofecoxib gained widespread acceptance among physicians treating patients with arthritis and other conditions causing chronic or acute pain. Worldwide, over 80 million people were prescribed rofecoxib at some time.

On September 30, 2004, Merck withdrew rofecoxib from the market because of concerns about increased risk of heart attack and stroke associated with long-term, high-dosage use. Merck withdrew the drug after disclosures that it withheld information about rofecoxib's risks from doctors and patients for over five years, resulting in between 88,000 and 140,000 cases of serious heart disease. Rofecoxib was one of the most widely used drugs ever to be withdrawn from the market. In the year before withdrawal, Merck had sales revenue of US$2.5 billion from Vioxx. Merck reserved $970 million to pay for its Vioxx-related legal expenses through 2007, and has set aside $4.85bn for legal claims from US citizens.

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Cause To Be Alarmed

by: Fixx

A little kid goes from
size one to size two
still we have same job
what is it that we do
all the change that's going on
in that tiny mind
still we're indecisive,
still we're wasting time
and there's cause, cause,
cause to be alarmed
who feeds the dove
who gives the world its charm
cause, cause, cause to be alarmed
we are pumped up fantasies
until the world's disarmed
a little hungry face
deserved more than roots to chew
they will erupt "enough's enough"
they'll lay the blame on you
and these perceiving minds observe
to count the final score
no treasure chest, to reinvest
just a bunch of whores
and there is cause, cause,
cause to be alarmed
no making love
until the world's disarmed
cause, cause, cause to be alarmed
a frigid little fantasy
until the world's disarmed
fly bird high bird
a love bird got shot
heard the lead bird's a dead bird
a new mind goes from birth,
to full view to old fool
still we have the same face
just what do we achieve?
all these minds that think alike
do damage to the strain
where we stand the very spot
we will not stand again
and there is cause, cause,
cause to be alarmed
who feeds the dove
who gives the world its charm
cause, cause, cause to be alarmed
we are pumped up fantasies
until the world is disarmed
fly bird high bird
go see bird and tell bird
that a love bird got shot,




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