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Proto-oncogene tyrosine-protein kinase Src

Proto-oncogene tyrosine-protein kinase Src, also known as proto-oncogene c-Src or simply c-Src , is a non-receptor tyrosine kinase protein that in humans is encoded by the SRC gene. This protein phosphorylates specific tyrosine residues in other proteins. An elevated level of activity of c-Src tyrosine kinase is suggested to be linked to cancer progression by promoting other signals. c-Src includes an SH2 domain, an SH3 domain, and a tyrosine kinase domain.

c-Src stands for "cellular Src kinase" and should not be confused with "C-terminal Src kinase" (CSK) which is an enzyme which phosphorylates c-Src at its C-terminus and provides negative regulation of Src's enzymatic activity. c-Src is a widely studied member of non-receptor tyrosine kinases which are not associated with a cell-surface receptor.

Src (pronounced "sarc" as it is short for sarcoma) is a proto-oncogene encoding a tyrosine kinase originally discovered by J. Michael Bishop and Harold E. Varmus, for which they were awarded the 1989 Nobel Prize in Physiology or Medicine. It belongs to a family of non-receptor tyrosine kinases called Src family kinases.

Nuclear receptor coactivator 2

The nuclear receptor coactivator 2 also known as NCoA-2 is a protein that in humans is encoded by the NCOA2 gene. NCoA-2 is also frequently called glucocorticoid receptor-interacting protein 1 (GRIP1), steroid receptor coactivator-2 (SRC-2), or transcriptional mediators/intermediary factor 2 (TIF2).

Function

NCoA-2 is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA2 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA2 in turn acetylates histones, which makes downstream DNA more accessible to transcription. Hence, NCOA2 assists nuclear receptors in the upregulation of DNA expression.

GRIP1 is a transcriptional co-activator of the glucocorticoid receptor and interferon regulatory factor 1 (IRF1).

Interactions

Nuclear receptor coactivator 2 has been shown to interact with:

Valerie

Valerie may refer to:

People

Songs

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See also

Valerie (film)

Valerie is a 1957 Western film starring Sterling Hayden, and Anita Ekberg and Anthony Steel, who were married at the time. It was their only film together

Plot

Rancher John Garth is arrested for critically wounding his wife Valerie and killing her parents. During the trial, we flashback to the lead up to the incident.

Cast

DVD

Valerie was released to DVD by MGM Home Video on September 26, 2011 vie MGM's MOD (manufacture-on-demand) program available through Amazon.

See also

References

External links

Valerie (Steve Winwood song)

"Valerie" is a song written by Steve Winwood and Will Jennings and originally recorded by Winwood for his third solo album Talking Back to the Night, in 1982.

Background

The song deals with a man reminiscing about a lost love he hopes to find again someday. Will Jennings reportedly wrote the lyrics while thinking about singer Valerie Carter, whose career was declining because of drugs. On its original release, the single reached number 51 on the UK Singles Chart and number 70 on the U.S. Billboard Hot 100.

In 1987, a remix by Tom Lord-Alge was included as a single from Winwood's compilation album Chronicles. The remixed version of "Valerie" climbed to number 9 on the Billboard Hot 100 in late December 1987, and also reached number 19 on the UK Singles Chart. Both versions also reached #13 on the Mainstream Rock Tracks chart.

DJ Falcon recalled in an interview that he and Thomas Bangalter, as a duo called Together, had sampled "Valerie" to create a simple loop that they used in DJ sets. Falcon added that the duo had no intention of releasing it as a single, despite demand from various outlets.