Vaccinia virus (VACV or VV) is a large, complex, enveloped virus belonging to the poxvirus family. It has a linear, double-stranded DNA genome approximately 190 kbp in length, and which encodes approximately 250 genes. The dimensions of the virion are roughly 360 × 270 × 250 nm, with a mass of approximately 5-10 fg.
Smallpox was the first disease to be widely prevented by vaccination due to pioneering work by the English physician and scientist Edward Jenner in the eighteenth century using cowpox virus. Vaccinia virus is the active constituent of the vaccine that eradicated smallpox, making it the first human disease to be eradicated. This endeavour was carried out by the World Health Organization under the Smallpox Eradication Program. Post eradication of smallpox, scientists study vaccinia virus to use as a tool for delivering genes into biological tissues (gene therapy and genetic engineering) and because of concerns about smallpox being used as an agent for bioterrorism.
I see her face in my dreams – like a star shining
all across the sea
I remember this moment – years ago there was only
you and me
When I wake up in sadness – I realize my deep
wounds never heal
Living only in memories – all is lost, coldness I
can feel
Sky turned darker and darker – soulless voices
whispering her name
End came closer and closer – endless sleep was
sweeping in her veins
She faded away – like a rose on a winterday
I remember her last words – please don´t cry for
Lost in endless night take me there, where I see you
again
Reach out for the light when will I break my pain
Come and fly with me all across the raging sea
Together we will be when will I ever be free
One night I was dreaming seemed to me like reality, so
clear
A fallen angel inside me speaks to me, tells me what
has to be done
There´s a fire in my heart burning bright like the
glory of a king
For too long I was waiting now my soul is flowing in
the wind
She faded away like a rose on a winterday
I remember her last words please don´t cry for me
Lost in endless night take me there, where I see you
again
Reach out for the light when will I break my pain
Come and fly with me all across the raging sea
Together we will be when will I ever be free
Lost in endless night take me there, where I see you
again
Reach out for the light when will I break my pain
Come and fly with me all across the raging sea