Vasoactive intestinal peptide receptor 2 also known as VPAC2, is a G-protein coupled receptor that in humans is encoded by the VIPR2 gene.
VIPR2 is expressed in the uterus, prostate, smooth muscle of the gastrointestinal tract, seminal vesicles and skin, blood vessels and thymus. VIPR2 is also expressed in the cerebellum.
Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) are homologous peptides that function as neurotransmitters and neuroendocrine hormones. While the receptors for VIP (VIRP 1 and 2) and PACAP (ADCYAP1R1) share homology, they differ in their substrate specificities and expression patterns. VIPR2 transduction results in upregulation of adenylate cyclase activity. Furthermore VIPR2 mediates the anti-inflammatory effects of VIP.
Research using VPAC2 knockout mice implicate it in the function of the circadian clock, growth, basal energy expenditure and male reproduction.
VIPR2 and/or PAC1 receptor activation is involved in cutaneous active vasodilation in humans.
I threw your keys in the water, I looked back,
Theyd frozen halfway down in the ice.
They froze up so quickly, the keys and their owners,
Even after the anger, it all turned silent, and
The everyday turned solitary,
So we came to February.
First we forgot where wed planted those bulbs last year,
Then we forgot that wed planted at all,
Then we forgot what plants are altogether,
and I blamed you for my freezing and forgetting and
The nights were long and cold and scary,
Can we live through February?
You know I think Christmas was a long red glare,
Shot up like a warning, we gave presents without cards,
And then the snow,
And then the snow came, we were always out shoveling,
And wed drop to sleep exhausted,
Then wed wake up, and its snowing.
And February was so long that it lasted into March
And found us walking a path alone together.
You stopped and pointed and you said, "Thats a crocus,"
And I said, "Whats a crocus?" and you said, "Its a flower,"
I tried to remember, but I said, "Whats a flower?"
You said, "I still love you."
The leaves were turning as we drove to the hardware store,
My new lover made me keys to the house,
And when we got home, well we just started chopping wood,
Because you never know how next year will be,
And well gather all our arms can carry,