Vasodilator-stimulated phosphoprotein

Vasodilator-stimulated phosphoprotein is a protein that in humans is encoded by the VASP gene.

Function

Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an N-terminal EVH1 domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions cell membranes. In the mid-region of the protein, family members have a proline-rich region that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG.

Interactions

Vasodilator-stimulated phosphoprotein has been shown to interact with Zyxin,Profilin 1 and PFN2.

VASP

Viação Aérea São Paulo S/A or VASP was an airline with its head office in the VASP Building on the grounds of Congonhas-São Paulo Airport in São Paulo, Brazil. It had main bases at Congonhas Airport (CGH) and Guarulhos International Airport (GRU), São Paulo.

History

The airline was established on 4 November 1933 by the state government of São Paulo and started operations in 1933. VASP was the first airline to serve the interior of the state of São Paulo (São Paulo-São Carlos-São José do Rio Preto and São Paulo-Ribeirão Preto-Uberaba), with two Monospar ST-4. At the start of the 1930s, it was the only carrier to operate with land planes. At the time this was a real exploit due to the lack of adequate non-coastal airports. Many landing strips were improvised in flat pastures. This insistence on using only land planes led to the building in 1936 of one of the country’s most important airports, Congonhas, located in the city of São Paulo, far from the coast. During its early years, Congonhas Airport was popularly known as Campo da VASP ("VASP's [Air]field").

VASP (disambiguation)

VASP can refer to:

Gene

A gene is a locus (or region) of DNA that encodes a functional RNA or protein product, and is the molecular unit of heredity. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. Most biological traits are under the influence of polygenes (many different genes) as well as the gene–environment interactions. Some genetic traits are instantly visible, such as eye colour or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that comprise life.

Genes can acquire mutations in their sequence, leading to different variants, known as alleles, in the population. These alleles encode slightly different versions of a protein, which cause different phenotype traits. Colloquial usage of the term "having a gene" (e.g., "good genes," "hair colour gene") typically refers to having a different allele of the gene. Genes evolve due to natural selection or survival of the fittest of the alleles.

Eugene (given name)

Eugene is a common (masculine) first name that comes from the Greek εὐγενής (eugenēs), "noble", literally "well-born", from εὖ (eu), "well" and γένος (genos), "race, stock, kin".Gene is a common shortened form. The feminine variant is Eugenia or Eugénie.

Male foreign-language variants include:

Notable people

Christianity

Military

Gene (novel)

Gene is a thriller novel by Stel Pavlou (born 1970), published in 2005 in England by Simon & Schuster. It is published in several languages with some title changes. The Italian edition has the title La Conspirazione del Minotauro (The Minotaur Conspiracy). The novel is about a fictional New York detective, James North, who in the process of hunting down a criminal, uncovers a genetics experiment to unlock past lives through genetic memory, therefore achieving a kind of immortality. In so doing North discovers his own origins, that of a soldier from the Trojan War who is reincarnated seven times through history, forced to confront his nemesis each time, all for the loss of his one true love.

Characters

Cyclades (born circa 1300 BC)

Incarnations of Cyclades

Athanatos (born circa 1500 BC)

Incarnations of Athanatos