Uridine monophosphate
Uridine monophosphate, also known as 5'-uridylic acid and abbreviated UMP, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid with the nucleoside uridine. UMP consists of the phosphate group, the pentose sugar ribose, and the nucleobase uracil; hence, it is a ribonucleoside monophosphate. Another common shorthand for the molecule is uridylate - the deprotonated form of the molecule, which is predominant in aqueous solution. As a substituent it takes the form of the prefix uridylyl-. The deoxy form is abbreviated dUMP.
Biosynthesis
Uridine monophosphate is formed from Orotidine 5'-monophosphate (orotidylic acid) in a decarboxylation reaction catalyzed by the enzyme orotidylate decarboxylase. Uncatalyzed, the decarboxylation reaction is extremely slow (estimated to occur on average one time per 78 million years). Adequately catalyzed, the reaction takes place once per second, an increase of 1017-fold.
In humans, the orotidylate decarboxylase function is carried out by the protein UMP synthase. Defective UMP synthase can result in orotic aciduria, a metabolic disorder.
Podcasts:
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by Noa
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by Tally Hall
Worry Doll
by: Noalists
i make lists
of all the things that i need to fix
of all the things that I'm not prepared for
of all the many things that i dread
lists
i make lists
of all the things i tried for, but missed
of all the things i gave up, but cared for
of all the words of love left unsaid
dream, without fear
your indian worry doll's here
under god's pillow so small
so that way you wont worry at all
dream, without fear
your indian worry doll's here
under god's pillow so small
so that way you won't have to worry at all
lists
very long
of all the things that I'm doing wrong
of all of the hysteria pending
of all the things I'd love to forget
lists
very deep
of all the time i can't seem to keep
of all the songs that still have no ending
of all the ways to do better yet
dream, without fear
your indian worry doll's here
under god's pillow so small
so that way you won't worry at all
dream, without fear
your indian worry doll's here
under god's pillow so small