Down syndrome

Down syndrome (DS or DNS) or Down's syndrome, also known as trisomy 21, is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. It is typically associated with physical growth delays, characteristic facial features, and mild to moderate intellectual disability. The average IQ of a young adult with Down syndrome is 50, equivalent to the mental age of an 8- or 9-year-old child, but this varies widely.

The parents of the affected individual are typically genetically normal. The extra chromosome occurs by random chance. There is no known behavior or environmental factor that changes the risk. Down syndrome can be identified during pregnancy by prenatal screening followed by diagnostic testing, or after birth by direct observation and genetic testing. Since the introduction of screening, pregnancies with the diagnosis are often terminated. Regular screening for health problems common in Down syndrome is recommended throughout the person's life.

Armando Galarraga's near-perfect game

In a Major League Baseball game played on June 2, 2010, at Comerica Park in Detroit, Michigan, Detroit Tigers pitcher Armando Galarraga nearly became the 21st pitcher in Major League history to throw a perfect game. Facing the Cleveland Indians, Galarraga retired the first 26 batters he faced, but his bid for a perfect game was ended one out short when first base umpire Jim Joyce incorrectly ruled that Indians batter Jason Donald reached first base safely on a ground ball. Galarraga instead finished with a one-hit shutout in a 3–0 victory. He faced 28 batters and threw 88 pitches (67 strikes and 21 balls), striking out three. The game is sometimes referred to as the "28-out perfect game", the "Imperfect Game", or simply the "Galarraga game".

Joyce was tearful and apologetic to Galarraga after the game upon realizing he had made the incorrect call. Galarraga was forgiving and understanding of the mistake. Without irony, he told reporters after the game, "Nobody's perfect." Galarraga was the most prominent of the many people throughout Major League Baseball who subsequently voiced their support for Joyce. Unusually, the umpire met with both the pitcher and the media after the game to apologize for his error. The sportsmanship demonstrated by Galarraga and Joyce earned them both widespread praise for their handling of the incident.

Perfect game

A perfect game is defined by Major League Baseball as a game in which a pitcher (or combination of pitchers) pitches a victory that lasts a minimum of nine innings and in which no opposing player reaches base. Thus, the pitcher (or pitchers) cannot allow any hits, walks, hit batsmen, or any opposing player to reach base safely for any other reason: in short, "27 up, 27 down". The feat has been achieved 23 times in MLB history – 21 times since the modern era began in 1900, most recently by Félix Hernández of the Seattle Mariners on August 15, 2012.

A perfect game is also a no-hitter and a shutout. A fielding error that does not allow a batter to reach base, such as a misplayed foul ball, does not spoil a perfect game. Weather-shortened contests in which a team has no baserunners and games in which a team reaches first base only in extra innings do not qualify as perfect games under the present definition. The first confirmed use of the term "perfect game" was in 1908; the current definition of the term was formalized in 1991. Although it is possible for multiple pitchers to combine for a perfect game (as has happened 11 times at the major league level for a no-hitter), to date, every major league perfect game has been thrown by a single pitcher. In Nippon Professional Baseball, no-hitters or perfect games that use two or more pitchers are considered unofficial.

Three Up, Two Down

Three Up, Two Down is a British sitcom starring Michael Elphick and Angela Thorne that ran from 1985 to 1989. It was written by Richard Ommanney.

Cast

  • Michael Elphick - Sam Tyler
  • Angela Thorne - Daphne Trenchard
  • Lysette Anthony - Angie Tyler (née Trenchard)
  • Ray Burdis - Nick Tyler
  • John Grillo - Wilf Perkins (series 2 onwards)
  • Neil Stacy - Major Giles Bradshaw (series 2 and 3)
  • Vicki Woolf - Rhonda (series 3 and 4)
  • Simon Talbot - Eddy (series 3)
  • Dulcie Gray - Nanny
  • Plot

    Nick and Angie have just had a baby, and to help them financially they decide to rent out the basement. Both Nick's father, Sam Tyler, and Angie's mother, Daphne Trenchard, want the basement apartment and the only solution is to share. Sam is a Cockney, while Daphne is Cheltenham-bred and has not forgiven her daughter for marrying Nick, a 'common' photographer. Both Sam and Daphne are widowed, and stubborn. There is mutual contempt between Nick and Daphne: however, Angie is fond of Sam and is forever trying, against all the odds, to keep the peace between him and Daphne. The situation is exacerbated, from Series Two onwards, by the presence of Sam's gloomy and pessimistic zoo-keeper friend Wilf Perkins, who ends up sharing Sam's room, much to Daphne's icy displeasure. Further complications arise through Daphne's brief romance with a neighbour, the suave and crooked Major Giles Bradshaw, who is eventually sent to prison for acts of theft and fraud.

    Podcasts:

    PLAYLIST TIME:

    Up & Down

    by: Shinee

    Neo wae, neo wae, down-iya gibuni
    Oh wae, oh wae, cheok hamyeon cheok
    Neo wae, neo wae, eobiya gibuni oh wae
    Neo wae, neo wae, down-iya gibuni
    Oh wae, oh wae, cheok hamyeon cheok
    Neo wae, neo wae, eobiya gibuni oh wae
    Wae neoneun up, down gibuni maennal dalla nal iri jeori
    heundeulkka
    Jeo muneul deureoseon geu sungan buteo ni nunchiman
    boneun na
    Useo julkka, hey baby, oneureun baby
    Uljeokhae boilkka, hae baby, eotteolkka baby
    Jonjabeul sudo eobseo deoneun moreugesseo
    Neon machi rollercoaster ride
    Neo wae, neo wae, down-iya gibuni
    Oh wae, oh wae, cheok hamyeon cheok
    Neo wae, neo wae, eobiya gibuni oh wae
    Machi rollercoaster ride
    Neo wae, neo wae, down-iya gibuni
    Oh wae, oh wae, cheok hamyeon cheok
    Neo wae, neo wae, eobiya gibuni oh wae
    Machi rollercoaster ride
    Oneul kkaji one, two iteureun hayan misoro sesangeul
    naege da jul deushi,
    Crazy, crazy baby
    Chan baram ssaenssaen buldorok,
    Ssal ssalhan naren nae jonjaedo ineun deu
    Useo julkka, hey baby, oneureun baby
    Uljeokhae boilkka, hae baby, eotteolkka baby
    Jonjabeul sudo eobseo geuraeseo jaemi isseo
    Neon machi rollercoaster ride
    Neo wae, neo wae, down-iya gibuni
    Oh wae, oh wae, cheok hamyeon cheok
    Neo wae, neo wae, eobiya gibuni oh wae
    Neo wae, neo wae, down-iya gibuni
    Oh wae, oh wae, cheok hamyeon cheok
    Neo wae, neo wae, eobiya gibuni oh wae
    Machi rollercoaster ride
    Neomu geonjohan gwangye
    Geudae eok neullin gamjeong ije geuman anye hangye
    Neomunado datin malhaji motago geunyeo ape geuchin
    Modeun namja deureun da seongashin miso hanamaneuro do
    nuni bushin
    Yeojeonhi ireokedo gamanhi gyeshin ireon geunyeol, say
    Eotteokana, hey baby, eotteokae baby
    Amuri geuraedo, hey baby, joheun geol, baby girl
    Oh no, oh no, neomu yeppeo mwodeun modu ssagike dwae
    Oh no, oh no, neomu yeppeo, oh no
    Oh no, oh no, neomu yeppeo mwodeun modu ssagike dwae
    Oh no, oh no, neomu yeppeo, oh no
    Neo wae, neo wae, down-iya gibuni
    Oh wae, oh wae, cheok hamyeon cheok
    Neo wae, neo wae, eobiya gibuni oh wae
    Machi rollercoaster ride
    Oh no, oh no, neomu yeppeo mwodeun modu ssagike dwae
    Oh no, oh no, neomu yeppeo, oh no
    Down, down and down to the up, up down and back up
    again
    Wae tto shimuruk hae ine sashil jom jichigin hae
    Geunde eotteokae neomu ppareuge
    Nae juwiyeseo ireoke gadeukhi maemdo neunde
    Oneul hanbeon ttak hanbeon useo jumyeon geunyan neomeo
    ganeun geol
    Machi rollercoaster ride
    Machi rollercoaster ride
    Machi rollercoaster ride
    Machi rollercoaster ride
    Machi rollercoaster ride
    Machi rollercoaster ride
    Machi rollercoaster ride machi,
    Neon machi duryeowun rollercoaster ride




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