Ago

Ago or AGO may refer to:

People

Places

Other uses

Argonaute

The Argonaute protein family plays a central role in RNA silencing processes, as essential catalytic components of the RNA-induced silencing complex (RISC). RISC complex is responsible for the gene silencing phenomenon known as RNA interference (RNAi). Argonaute proteins bind different classes of small non-coding RNAs, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs). Small RNAs guide Argonaute proteins to their specific targets through sequence complementarity (base pairing), which then leads to mRNA cleavage or translation inhibition.

Discovery

The RNA interference (RNAi) was first reported in 1995 by Guo and Kemphues, and similar pathways collectively referred to as RNA silencing were discovered in plants and fungi. The beginning of people’s understanding of the mechanism of RNA silencing began only in 1998 with the experiments of Fire and colleagues demonstrating that double-stranded RNA triggered RNAi. RNA silencing pathways process long RNAs into small RNAs that direct the repression of transcription or translation of nucleic acid targets with sequence corresponding to the small RNAs. These single-stranded RNAs, referred to as guide strands, are incorporated into RNA silencing effectors complexes such as the RNA-induced silencing complex (RISC). These RNA silencing effector complexes contain Argonaute family proteins.

Unknown

Unknown or The Unknown may refer to:

Mathematics

Film

Music

Other uses

Unknown (2006 film)

Unknown is a 2006 American mystery thriller film directed by Colombian filmmaker Simon Brand and starring Jim Caviezel, Greg Kinnear, Bridget Moynahan, Joe Pantoliano and Barry Pepper about a group of men kidnapped and locked in a factory with no memory of how they arrived there. Piecing together information around them, they realize that some were kidnapped and some were the kidnappers. They decide they must work together to figure out how to get away before the gang that captured them returns.

The film was previewed before a theater audience for the first time in New York City on December 13, 2005.

Plot

In an abandoned warehouse, a handful of men slowly regain consciousness, but they have amnesia and have no idea who they are, where they are, or what has happened to them. All five seem to have been in some sort of serious scuffle; one is tied up on a chair (Joe Pantoliano), another has been handcuffed and shot (Jeremy Sisto), a third has a broken nose (Greg Kinnear), and the other two have their share of scrapes and bruises (Jim Caviezel and Barry Pepper). Everyone is asleep at the start. Caviezel's character wakes up first. He checks to make sure everyone is alive and then decides to walk around and try to find out what is going on. He discovers that all the windows have bars over them and the only door has a mechanized lock. He finds a ringing phone and picks it up. The caller asks what is going on and Caviezel tells the caller that everyone is fine. The Caller tells him he will be back in a few hours. Meanwhile, somewhere else a money drop off is going down. Mr. Coles has been kidnapped.

Jun Kazama

Jun Kazama (風間 準, Kazama Jun) is a fictional character from the Tekken fighting game series, who has made her debut in Tekken 2, her only canonical appearance to date. Following an ambiguous relationship with Kazuya Mishima, she became the mother of Jin Kazama, both of whom are main characters in the series. She is also related to Asuka Kazama and her father.

A nature lover and the mother of Jin Kazama, Jun plays an important role in the story despite of her absence for most of the series. While she was cut from the main series after her debut, Jun has continued to appear in the series' spin-offs, including the Tekken Tag Tournament series, where her alter-ego, Unknown serves as the final boss in all Tag Tournament entries so far. Despite her relatively few appearances, the character has gained a considerable popularity among the fans of the series.

Appearances

In video games