UBR5

E3 ubiquitin-protein ligase UBR5 is an enzyme that in humans is encoded by the UBR5 gene.

Function

This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation.

Interactions

UBR5 has been shown to interact with:

  • CIB1,
  • Karyopherin alpha 1,
  • MAPK1, and
  • TOPBP1.
  • References

    Further reading

    External links

  • Ubr5 : Protein Overview : UCSD-Nature Molecule Pages

  • Podcasts:

    PLAYLIST TIME:

    Wojtek - The Soldier Bear

    by: Obrero

    Coming from the wilderness
    Found by a little boy
    Sold to some soldiers
    He became their toy
    But soon they saw his value
    And made him one of them
    He helped them fight the evil
    Over and over again
    Woytek – the soldier bear
    Woytek – the soldier bear
    He bears the shells
    He eats syrup and honey
    But also cigarettes
    And he drinks beer
    Coming from the wilderness
    Found by a little boy
    Sold to some soldiers
    He became their toy
    But soon they saw his value
    And made him one of them
    He helped them fight the evil
    Over and over again
    Woytek – the soldier bear
    Woytek – the soldier bear
    He bears the shells
    He eats syrup and honey
    But also cigarettes
    And he drinks beer
    From the companies mascot
    To their official emblem
    The hero of the 22nd
    Not like any man
    Proud and tall he stands
    The grenades in his paws
    Marching of to war
    Strong forevermore
    From the companies mascot
    To their official emblem
    The hero of the 22nd
    Not like any man
    Proud and tall he stands
    The grenades in his paws
    Marching of to war
    Strong forevermore
    Woytek – the soldier bear




    ×