Ubiquitin-conjugating enzyme E2E 1

PDB rendering based on 1y6l.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols UBE2E1; UBCH6
External IDs OMIM: 602916 MGI: 107411 HomoloGene: 84372 GeneCards: UBE2E1 Gene
EC number 6.3.2.19
RNA expression pattern
PBB GE UBE2E1 212519 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7324 22194
Ensembl ENSG00000170142 ENSMUSG00000021774
UniProt P51965 P52482
RefSeq (mRNA) NM_001202476.1 NM_009455.3
RefSeq (protein) NP_001189405.1 NP_033481.1
Location (UCSC) Chr 3:
23.85 – 23.93 Mb		 Chr 14:
19.12 – 19.16 Mb
PubMed search [1] [2]
This box:

Ubiquitin-conjugating enzyme E2 E1 is a protein that in humans is encoded by the UBE2E1 gene.[1][2]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[2]

Interactions [link]

UBE2E1 has been shown to interact with Ataxin 1[3] and NEDD4.[4][5]

References [link]

  1. ^ Nuber U, Schwarz S, Kaiser P, Schneider R, Scheffner M (Mar 1996). "Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5". J Biol Chem 271 (5): 2795–800. DOI:10.1074/jbc.271.5.2795. PMID 8576257. 
  2. ^ a b "Entrez Gene: UBE2E1 ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7324. 
  3. ^ Hong, Sunghoi; Lee Soyeon, Cho Ssang-Goo, Kang Seongman (Jun. 2008). "UbcH6 interacts with and ubiquitinates the SCA1 gene product ataxin-1". Biochem. Biophys. Res. Commun. (United States) 371 (2): 256–60. DOI:10.1016/j.bbrc.2008.04.066. PMID 18439907. 
  4. ^ Anan, T; Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M (Nov. 1998). "Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes". Genes Cells (ENGLAND) 3 (11): 751–63. DOI:10.1046/j.1365-2443.1998.00227.x. ISSN 1356-9597. PMID 9990509. 
  5. ^ Malakhova, Oxana A; Zhang Dong-Er (Apr. 2008). "ISG15 Inhibits Nedd4 Ubiquitin E3 Activity and Enhances the Innate Antiviral Response". J. Biol. Chem. (United States) 283 (14): 8783–7. DOI:10.1074/jbc.C800030200. ISSN 0021-9258. PMC 2276364. PMID 18287095. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2276364. 

Further reading [link]
Chaperones/
protein folding
Other
Protein targeting
Ubiquitin

E1 Ubiquitin-activating enzyme (UBA1, UBA2, UBA3, UBA5, UBA6, UBA7, ATG7, NAE1, SAE1)

E2 Ubiquitin-conjugating enzyme (A • B • C • D1, D2, D3 • E1, E2, E3 • G1, G2 • H • I • J1, J2 • K • L1, L2, L3, L4, L6 • M • N • O • Q1, Q2 • R1 (CDC34), R2 • S • V1, V2 • Z)

E3 Ubiquitin ligase (VHL, Cullin, CBL, MDM2, FANCL, UBR1)

Deubiquitinating enzyme: Ataxin 3 • USP6 • CYLD

ATG3 • BIRC6 • UFC1
Other
Stub icon This article on a gene on chromosome 3 is a stub. You can help Wikipedia by expanding it.

https://wn.com/UBE2E1

Podcasts:

Email this Page Play all in Full Screen Show More Related Videos
PLAYLIST TIME:

Back Up

by: Webbie

Girl you're too sexy
come and sit with me in V.I.P.
With those curves and cocoa skin
now where have you been
The tattoo on your belly's kinda hot
them about a shorty in the spot
You came in with a man
but I'm making plaaans
to be next to you
been checking out the rest and they just wont do
pretty young thing in a lexus coupe
been praying everyday to blessed with you (blessed with you)
but I am next to you
all I think about is undressing you
playing all alone just to touch with you
can we get it on in my bedroom
would ya mind
would ya mind
if I got to know ya better baby
your my type
and I really really want you lady so
make up your mind
do you want him or do you want me
take your time
its alright, I dont mind
I see ya checking out my rings and the platinum watch
your trying to figure out what I'm not
the keys to my range around my neck
and a legit royalty check
if ya looking for someone who has nice things
someone to give ya all the love you need
look no further I'm that man
and I got a plaaan
I wanna take ya home
get ya all alone
turn the lights down low
to a private show
kiss ya from head to toe
take off all your clothes
throw em on the floor
make a video
baby come stay awhile
you cant deny
what ya feel inside
its in your eyes
make up your mind
stop wasting time
baby its alright
would ya mind
I wanna take ya home
get ya all alone
turn the lights down low
to a private show
kiss ya from head to toe
take off all your clothes
throw em on the floor
make a video
baby come stay awhile
you cant deny
what ya feel inside
its in your eyes
make up your mind




×
×
×
×