SLC22A12
Solute carrier family 22 (organic anion/cation transporter), member 12, also known as SLC22A12 and URAT1, is a protein which in humans is encoded by the SLC22A12 gene.
Function
The protein encoded by this gene is a urate transporter and urate-anion exchanger which regulates the level of urate in the blood. This protein is an integral membrane protein primarily found in kidney. Two transcript variants encoding different isoforms have been found for this gene.
Clinical significance
Numerous single nucleotide polymorphisms of this gene are significantly associated with altered (increased or decreased) reabsorption of uric acid by the kidneys. Respectively, these altered rates of reabsorption contribute to hyperuricemia and hypouricemia.
See also
Interactions
SLC22A12 has been shown to interact with PDZK1.
Inhibition
Lesinurad is an urate transporter inhibitor that has been approved to treat gout. Lesinurad enhances urate excretion by inhibition the tubular re-absorption. Probenecid also facilitates uric acid secretion.
Podcasts:
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by Airdate
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by Airdate
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by Airdate
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by Airdate
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by Airdate
Everytime
by: AirdateYou, were always the kind of girl to call me at 3am,
We were only best of friends.
I, kept this secret kept a lie, deep down locked inside,
But I've got nothing left to hide.
I've got feelings that I can't deny.
Everytime you fall,
I will pick you up baby.
Everytime you fall,
I won't let your heart hit the ground.
I'll always be around.
I'll never ever let you down.
Me, Just put a little faith in me.
I am trying hard to make you see,
That we were always meant to be.
I, I am not just your typical guy.
I'll never let a day go by,
Without you here by my side.
I've got feelings that I can't deny.
Everytime you fall,
I will pick you up baby.
Everytime you fall,
I won't let your heart hit the ground.
I will always be around.
Everytime you fall,
I will pick you up baby.
(down, down, down, baby)
I'll never ever let you down.
Everytime you fall,
I will pick you up baby.
Everytime you fall,
I won't let your heart hit the ground.
I will always be around.
I'll never ever let you down.