On October 21, it was announced that a previous matchup between welterweight contenders Thiago Alves and Paulo Thiago had been changed to Alves vs. Jon Fitch because Fitch's opponent for UFC 106, Ricardo Almeida, suffered an injury. Paulo Thiago fought on UFC 106 on November 21 against UFC newcomer Jacob Volkmann and won the fight by unanimous decision.
It was then announced on October 30 that Fitch would again be without an opponent as Alves was forced to withdraw because of a posterior cruciate ligament tear. It was later announced that Jon Fitch would face Mike Pierce at UFC 107.
A middleweight bout between Alan Belcher and Wilson Gouveia was changed to a 195-pound catchweight bout after Gouveia asked for a 190-pound catchweight limit, but Belcher gave a counter-offer of 195 pounds.