Ubiquitin-protein ligase E3A (UBE3A) also known as E6AP ubiquitin-protein ligase (E6AP) is an enzyme that in humans is encoded by the UBE3A gene. This enzyme is involved in targeting proteins for degradation within cells.
Protein degradation is a normal process that removes damaged or unnecessary proteins and helps maintain the normal functions of cells. Ubiquitin protein ligase E3A attaches a small marker protein called ubiquitin to proteins that should be degraded. Cellular structures called proteasomes recognize and digest proteins tagged with ubiquitin.
Both copies of the UBE3A gene are active in most of the body's tissues. In the brain, however, only the copy inherited from a person's mother (the maternal copy) is normally active; this is known as paternal imprinting. The UBE3A gene is located on the long (q) arm of chromosome 15 between positions 11 and 13, from base pair 23,133,488 to base pair 23,235,220.
Mutations within the UBE3A gene are responsible for some cases of Angelman syndrome and Prader-Willi syndrome. Most of these mutations result in an abnormally short, nonfunctional version of ubiquitin protein ligase E3A. Because the copy of the gene inherited from a person's father (the paternal copy) is normally inactive in the brain, a mutation in the remaining maternal copy prevents any of the enzyme from being produced in the brain. This loss of enzyme function likely causes the characteristic features of these two conditions.
Girl you're too sexy
come and sit with me in V.I.P.
With those curves and cocoa skin
now where have you been
The tattoo on your belly's kinda hot
them about a shorty in the spot
You came in with a man
but I'm making plaaans
to be next to you
been checking out the rest and they just wont do
pretty young thing in a lexus coupe
been praying everyday to blessed with you (blessed with you)
but I am next to you
all I think about is undressing you
playing all alone just to touch with you
can we get it on in my bedroom
would ya mind
would ya mind
if I got to know ya better baby
your my type
and I really really want you lady so
make up your mind
do you want him or do you want me
take your time
its alright, I dont mind
I see ya checking out my rings and the platinum watch
your trying to figure out what I'm not
the keys to my range around my neck
and a legit royalty check
if ya looking for someone who has nice things
someone to give ya all the love you need
look no further I'm that man
and I got a plaaan
I wanna take ya home
get ya all alone
turn the lights down low
to a private show
kiss ya from head to toe
take off all your clothes
throw em on the floor
make a video
baby come stay awhile
you cant deny
what ya feel inside
its in your eyes
make up your mind
stop wasting time
baby its alright
would ya mind
I wanna take ya home
get ya all alone
turn the lights down low
to a private show
kiss ya from head to toe
take off all your clothes
throw em on the floor
make a video
baby come stay awhile
you cant deny
what ya feel inside
its in your eyes
make up your mind