Ubiquitin-like modifier activating enzyme 1 (UBA1) is an enzyme which in humans is encoded by the UBA1 gene. UBA1 participates in ubiquitination and the NEDD8 pathway for protein folding and degradation, among many other biological processes. This protein has been linked to X-linked spinal muscular atrophy type 2, neurodegenerative diseases, and cancers.
The protein encoded by this gene catalyzes the first step in ubiquitin conjugation, or ubiquitination, to mark cellular proteins for degradation. Specifically, UBA1 catalyzes the ATP-dependent adenylation of ubiquitin (Ub), thereby forming a thioester bond between the two. It also continues to participate in subsequent steps of ubiquination as a Ub carrier. UBA1 is one of only two human ubiquitin-activating enzymes (E1), the other being UBA6, and thus is largely responsible for protein ubiquitination in humans. Through its central role in ubiquitination, UBA1 has been linked to cell cycle regulation, endocytosis, signal transduction, apoptosis, DNA damage repair, and transcriptional regulation. Additionally, UBE1 helps regulate the NEDD8 pathway, thus implicating it in protein folding, as well as mitigating the depletion of ubiquitin levels during stress.
Girl you're too sexy
come and sit with me in V.I.P.
With those curves and cocoa skin
now where have you been
The tattoo on your belly's kinda hot
them about a shorty in the spot
You came in with a man
but I'm making plaaans
to be next to you
been checking out the rest and they just wont do
pretty young thing in a lexus coupe
been praying everyday to blessed with you (blessed with you)
but I am next to you
all I think about is undressing you
playing all alone just to touch with you
can we get it on in my bedroom
would ya mind
would ya mind
if I got to know ya better baby
your my type
and I really really want you lady so
make up your mind
do you want him or do you want me
take your time
its alright, I dont mind
I see ya checking out my rings and the platinum watch
your trying to figure out what I'm not
the keys to my range around my neck
and a legit royalty check
if ya looking for someone who has nice things
someone to give ya all the love you need
look no further I'm that man
and I got a plaaan
I wanna take ya home
get ya all alone
turn the lights down low
to a private show
kiss ya from head to toe
take off all your clothes
throw em on the floor
make a video
baby come stay awhile
you cant deny
what ya feel inside
its in your eyes
make up your mind
stop wasting time
baby its alright
would ya mind
I wanna take ya home
get ya all alone
turn the lights down low
to a private show
kiss ya from head to toe
take off all your clothes
throw em on the floor
make a video
baby come stay awhile
you cant deny
what ya feel inside
its in your eyes
make up your mind