Uba

Uba or UBA (and diacritic variations) may refer to:

Place names

Abbreviations

Ubaí

Ubaí is a municipality in the north of the Brazilian state of Minas Gerais. As of 2007 the population was 11,834 in a total area of 821 km². It became a municipality in 1962.

Location

Ubaí is located at an elevation of 608 meters between the São Francisco River and Brasília de Minas. It is connected by state highway (partially paved) to São Romão on the São Francisco River. It belongs to the statistical microregion of Montes Claros. Neighboring municipalities are Ponto Chique, São Romão, Campo Azul, Luislândia and Icaraí de Minas. The Rio Gameleiras crosses the south of the municipal area.

Distances

Economic activities

The most important economic activities are cattle raising, commerce, and subsistence agriculture. The GDP in 2005 was R$ 29,109,000. Ubaí is in the bottom tier of municipalities in the state with regard to economic and social development. It suffers from isolation, poor soils, and periodic drought. As of 2007 there was 01 banking agency in the town. There was a small retail commerce serving the surrounding area of cattle and agricultural lands. In the rural area there were 858 establishments employing about 2,500 workers. Only 37 of the farms had tractors. There were 101 automobiles in all of the municipality. There were 35,000 head of cattle in 2006. The crops with a planted area of more than 100 hectares were beans, sugarcane, manioc, and corn.

UBA2

Ubiquitin-like 1-activating enzyme E1B (UBLE1B) also known as SUMO-activating enzyme subunit 2 (SAE2) is an enzyme that in humans is encoded by the UBA2 gene.

Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins.

Structure

DNA

The UBA2 cDNA fragment 2683 bp long and encodes a peptide of 640 amino acids. The predicted protein sequence is more analogous to yeast UBA2 (35% identity) than human UBA3 or E1 (in ubiquitin pathway). The UBA gene is located on chromosome 19.

Protein

Uba2 subunit is 640 aa residues long with a molecular weight of 72 kDa. It consists of three domains: an adenylation domain (containing adenylation active site), a catalytic Cys domain (containing the catalytic Cys173 residue participated in thioester bond formation), and an Ubiquitin-Like domain. SUMO-1 binds on Uba2 between the catalytic Cys domain and UbL domain.