U2AF2
Splicing factor U2AF 65 kDa subunit is a protein that in humans is encoded by the U2AF2 gene.
Function
U2 auxiliary factor (U2AF), composed of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit, which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple alternatively spliced transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date.
Interactions
U2AF2 has been shown to interact with:
References
Further reading
Podcasts:
I. F. Y.
by: VaderOriginally performed by Depeche Mode
Music: Depeche Mode / Lyrics: Piotr Wiwczarek
I feel you
Your son is dead
I feel you
Within my mind
You're fearing me
Still fearing me
My kingdom comes
You tried to do
To lead me through eternity
But this is the morning of our law
And this is the dawning of our law
I hear you
Your fadin' voice
I feel you
Die on the cross
The joy it brings
When heaven burns
Your golden gates
Don't try to do
'Cause I'll kill you eternally
This is the dawning of fallen one
And this is is the fall of your nailed son
I kill you
Your holy soul
And I kill more
I feel you
Your suffer-son
My kingdom comes
I feel you
Each move you make
I feel you
What for you wait
Where angels sing
I spread my wings
See my rebirth
I'll take you down
To glory's throne
Don't ask me... why?