Txnip

Thioredoxin interacting protein

Identifiers

TXNIP; EST01027; HHCPA78; THIF; VDUP1

External IDs

OMIM: 606599 MGI: 1889549 HomoloGene: 38186 GeneCards: TXNIP Gene

Gene Ontology
Molecular function	• enzyme inhibitor activity • protein binding • ubiquitin protein ligase binding
Cellular component	• nucleus • cytoplasm • mitochondrial intermembrane space • cytosol
Biological process	• negative regulation of transcription from RNA polymerase II promoter • regulation of transcription, DNA-dependent • protein import into nucleus • response to oxidative stress • cell cycle • response to mechanical stimulus • response to glucose stimulus • keratinocyte differentiation • response to estradiol stimulus • response to progesterone stimulus • nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway • regulation of cell proliferation • response to drug • response to hydrogen peroxide • positive regulation of apoptotic process • innate immune response • platelet-derived growth factor receptor signaling pathway • response to calcium ion • negative regulation of cell division • cellular response to tumor cell
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
145.44 – 145.44 Mb

Chr 3:
96.36 – 96.37 Mb

PubMed search

[1]

[2]

Thioredoxin-interacting protein is a protein that in humans is encoded by the TXNIP gene.^[1]^[2]

1 Interactions
2 Related gene problems
3 References
4 Further reading

Interactions [link]

TXNIP has been shown to interact with Thioredoxin^[3] and ZBTB32.^[4]

References [link]

^ Chen KS, DeLuca HF (Oct 1994). "Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3". Biochim Biophys Acta 1219 (1): 26–32. PMID 8086474.
^ "Entrez Gene: TXNIP thioredoxin interacting protein". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10628.
^ Nishiyama, A; Matsui M, Iwata S, Hirota K, Masutani H, Nakamura H, Takagi Y, Sono H, Gon Y, Yodoi J (Jul. 1999). "Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression". J. Biol. Chem. (UNITED STATES) 274 (31): 21645–50. DOI:10.1074/jbc.274.31.21645. ISSN 0021-9258. PMID 10419473.
^ Han, Seung Hyun; Jeon Jun Ho, Ju Hyang Ran, Jung Uhee, Kim Kun Young, Yoo Hyang Sook, Lee Young Ho, Song Kyu Sang, Hwang Ho Myeung, Na Yoon Sook, Yang Young, Lee Kee Nyung, Choi Inpyo (Jun. 2003). "VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression". Oncogene (England) 22 (26): 4035–46. DOI:10.1038/sj.onc.1206610. ISSN 0950-9232. PMID 12821938.

Further reading [link]

Nishiyama A, Matsui M, Iwata S, et al. (1999). "Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression.". J. Biol. Chem. 274 (31): 21645–50. DOI:10.1074/jbc.274.31.21645. PMID 10419473.
Ludwig DL, Kotanides H, Le T, et al. (2001). "Cloning, genetic characterization, and chromosomal mapping of the mouse VDUP1 gene.". Gene 269 (1-2): 103–12. DOI:10.1016/S0378-1119(01)00455-3. PMID 11376942.
Bodnar JS, Chatterjee A, Castellani LW, et al. (2002). "Positional cloning of the combined hyperlipidemia gene Hyplip1.". Nat. Genet. 30 (1): 110–6. DOI:10.1038/ng811. PMC 2846781. PMID 11753387. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2846781.
Joguchi A, Otsuka I, Minagawa S, et al. (2002). "Overexpression of VDUP1 mRNA sensitizes HeLa cells to paraquat.". Biochem. Biophys. Res. Commun. 293 (1): 293–7. DOI:10.1016/S0006-291X(02)00208-5. PMID 12054598.
Butler LM, Zhou X, Xu WS, et al. (2002). "The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin.". Proc. Natl. Acad. Sci. U.S.A. 99 (18): 11700–5. DOI:10.1073/pnas.182372299. PMC 129332. PMID 12189205. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=129332.
Schulze PC, De Keulenaer GW, Yoshioka J, et al. (2002). "Vitamin D3-upregulated protein-1 (VDUP-1) regulates redox-dependent vascular smooth muscle cell proliferation through interaction with thioredoxin.". Circ. Res. 91 (8): 689–95. DOI:10.1161/01.RES.0000037982.55074.F6. PMID 12386145.
Han SH, Jeon JH, Ju HR, et al. (2003). "VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression.". Oncogene 22 (26): 4035–46. DOI:10.1038/sj.onc.1206610. PMID 12821938.
Champliaud MF, Viel A, Baden HP (2003). "The expression of vitamin D-upregulated protein 1 in skin and its interaction with sciellin in cultured keratinocytes.". J. Invest. Dermatol. 121 (4): 781–5. DOI:10.1046/j.1523-1747.2003.12539.x. PMID 14632196.
Kim KY, Shin SM, Kim JK, et al. (2004). "Heat shock factor regulates VDUP1 gene expression.". Biochem. Biophys. Res. Commun. 315 (2): 369–75. DOI:10.1016/j.bbrc.2004.01.047. PMID 14766217.
Schulze PC, Yoshioka J, Takahashi T, et al. (2004). "Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein.". J. Biol. Chem. 279 (29): 30369–74. DOI:10.1074/jbc.M400549200. PMID 15128745.
Coon H, Singh N, Dunn D, et al. (2004). "TXNIP gene not associated with familial combined hyperlipidemia in the NHLBI Family Heart Study.". Atherosclerosis 174 (2): 357–62. DOI:10.1016/j.atherosclerosis.2004.02.004. PMID 15136067.
Nishinaka Y, Masutani H, Oka S, et al. (2004). "Importin alpha1 (Rch1) mediates nuclear translocation of thioredoxin-binding protein-2/vitamin D(3)-up-regulated protein 1.". J. Biol. Chem. 279 (36): 37559–65. DOI:10.1074/jbc.M405473200. PMID 15234975.
Aitken CJ, Hodge JM, Nishinaka Y, et al. (2005). "Regulation of human osteoclast differentiation by thioredoxin binding protein-2 and redox-sensitive signaling.". J. Bone Miner. Res. 19 (12): 2057–64. DOI:10.1359/JBMR.040913. PMID 15537450.
Yamawaki H, Pan S, Lee RT, Berk BC (2005). "Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cells.". J. Clin. Invest. 115 (3): 733–8. DOI:10.1172/JCI200523001. PMC 546457. PMID 15696199. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=546457.
Minn AH, Hafele C, Shalev A (2005). "Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis.". Endocrinology 146 (5): 2397–405. DOI:10.1210/en.2004-1378. PMID 15705778.

This article on a gene on chromosome 1 is a stub. You can help Wikipedia by expanding it.

https://wn.com/TXNIP

Podcasts:

Email this Page Play all in Full Screen Show More Related Videos

Most Related
Most Recent
Most Popular
Top Rated

PLAYLIST TIME:

Contents

Interactions [link]

Related gene problems [link]

References [link]

Further reading [link]

https://wn.com/TXNIP

Podcasts:

EXPLORE WN.com