A triol is a chemical compound containing three hydroxyl groups (–OH functional groups),[1] such as glycerol. An example of triol on benzene is benzenetriol.

See also [link]

  • Alcohols, chemical compounds with one hydroxyl group
  • Diols, chemical compounds with two hydroxyl groups
  • Polyols, chemical compounds with multiple hydroxyl groups
  • Phenol, chemical compound with a hydroxyl group bonded to a benzene ring

References [link]

  1. ^ Alcohols, Ethers, Thiols and Chirality
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1,2,4-Butanetriol

1,2,4-Butanetriol is a clear or slightly yellow, odorless, hygroscopic, flammable, viscous liquid. It is an alcohol with three hydrophilic alcoholic hydroxyl groups. It is similar to glycerol and erythritol. It is chiral, with two possible enantiomers.

1,2,4-Butanetriol is used in the manufacture of butanetriol trinitrate (BTTN), an important military propellant.

1,2,4-Butanetriol is also used as a precursor for two cholesterol-lowering drugs, Crestor and Zetia, which are derived from D-3,4-dihydroxybutanoic acid, by using 3-hydroxy-gamma-butyrolactone as a chiral synthon Niu, W (2003). "Microbial synthesis of the energetic material precursor 1,2,4-butanetriol". Am. Chem. Soc. 125 (43): 12998–12999. doi:10.1021/ja036391+.  "Biosynthetic Pathways". Retrieved 24 November 2010. . It is as one of the monomers for manufacture of some polyesters and as a solvent.

1,2,4-Butanetriol can be prepared synthetically by several different methods such as hydroformylation of glycidol and subsequent reduction of the product, sodium borohydride reduction of esterified malic acid, or catalytic hydrogenation of malic acid. However, of an increasing importance is the biotechnological synthesis using genetically engineered Escherichia coli and Pseudomonas fragi bacteria.

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