TRIB3

Tribbles homolog 3 is a protein that in humans is encoded by the TRIB3 gene.

Function

The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB, and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1.

Interactions

TRIB3 has been shown to interact with:

References

Further reading