Nuclear receptor coactivator 3

The nuclear receptor coactivator 3 also known as NCOA3 is a protein that, in humans, is encoded by the NCOA3 gene. NCOA3 is also frequently called 'amplified in breast 1' (AIB1), steroid receptor coactivator-3 (SRC-3), or thyroid hormone receptor activator molecule 1 (TRAM-1).

Function

NCOA3 is a transcriptional coactivator protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA3 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA3, in turn, acylates histones, which makes downstream DNA more accessible to transcription. Hence, NCOA3 assists nuclear receptors in the upregulation of gene expression.

Clinical significance

The ratio of PAX2 to AIB-1 protein expression may be predictive of the effectiveness of tamoxifen in breast cancer treatment.

Interactions

Nuclear receptor coactivator 3 has been shown to interact with:

Sick

Sick may refer to:

Music

Albums

Songs

Other media

People with the surname

Sick (Loaded album)

Sick is the second studio album by American hard rock band Loaded. It is their first album since reforming after they went on hiatus in 2002. It was recorded and produced by Martin Feveyear at Jupiter Studios in Seattle, Washington, and was released on March 30, 2009 in Europe and April 7 in the US, through Century Media Records. Writing for the album began in 2008 when vocalist Scott Weiland departed Duff McKagan's other band, Velvet Revolver, in April of the same year. Recording for the follow-up to their 2001 debut album Dark Days began and was completed in June 2008.

Following the release of the album, Loaded went on to promote it for over half a year; releasing one single, "Flatline", and touring in several regions, including the United States, South America and several countries in Europe as well as playing at several music festivals. The album received generally positive reviews, many of which made some comparisons to McKagan's former band, Guns N' Roses.

Background and production

Sick (song)

"Sick" is the first single from Adelitas Way's second studio album, Home School Valedictorian, released on March 11, 2011.It is the band's third single in overall. This the band's first single to hit the Billboard Alternative Rock Song chart reaching No. 29 and staying on the chart for 14 weeks. The song reached No. 2 on the U.S Mainstream Rock chart.

Music video

The music video for "Sick", which was directed by Michael Maxxis, premiered on May 12, 2011. The video was filmed in the Griffith Park Tunnel in Los Angeles, CA.

Track listing

References

External links

Bayé

Bayé is a town in the Solenzo Department of Banwa Province in western Burkina Faso. As of 2005 it had a population of 5,478.

References

Coordinates: 12°04′N 4°05′W / 12.067°N 4.083°W / 12.067; -4.083

Bay (shelving)

A bay is a basic unit of library shelving. Bays are book cases about 3 feet (0.9 m) wide. Bays are stuck together in rows. Items are shelved from the top shelf to the bottom shelf in each bay.

Rows consist of a number of bays, either single-sided or double-sided, connected to each other. The standard length of a row is five to six bays, but it is not uncommon to find rows seven bays wide or even wider. In some countries a row is referred to as a 'stack' or a 'range'.

References

Bay (chancellor)

Bay, also called Ramesse Khamenteru, (died 1192 BC) was an important Asiatic official in ancient Egypt, who rose to prominence and high office under Seti II Userkheperure Setepenre and later became an influential powerbroker in the closing stages of the 19th Dynasty. He was generally identified with Irsu (alt. Arsu, Iarsu, Yarsu) mentioned in the Great Harris Papyrus, although no contemporary source connects Bay with Irsu.

Bay's importance is emphasized by the fact that he was given permission, possibly by Seti but more probably by Siptah, to construct his own tomb in Egypt's Valley of the Kings (KV13). His tomb was clearly constructed as part of a triad of tombs, including that of the Pharaoh Siptah and Queen Twosret. This was an unprecedented privilege, the likes of which were rarely accorded to a commoner, let alone a foreigner (though previous exceptions, such as that of Yuya, have occurred). It is possible that Bay was accorded this tomb because he was a relation of Siptah's mother, a Canaanite concubine of Seti II, or perhaps even of Amenmesse. His tomb was later usurped under the Twentieth Dynasty by prince Mentuherkhepshef, a son of Ramesses IX.