TRAF5
TNF receptor-associated factor 5 is a protein that in humans is encoded by the TRAF5 gene.
Function
The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Alternate transcriptional splice variants have been characterized.
Interactions
TRAF5 has been shown to interact with:
ASK1,
CD134,
CD30,
CD40,
RANK
TNFRSF13B, and
TNFRSF14.
References
Further reading