TOPBP1

DNA topoisomerase 2-binding protein 1 is an enzyme that in humans is encoded by the TOPBP1 gene.

Function

This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands.

Interactions

TOPBP1 has been shown to interact with:

Clinical relevance

This gene may be involved in the development of ovarian and breast cancer.

Mutations in TOPBP1 cause Idiopathic pulmonary arterial hypertension .

References

Further reading