Tolerance

Tolerance or toleration is the state of tolerating, or putting up with, conditionally.

Engineering tolerance

Engineering tolerance is the permissible limit or limits of variation in:

Dimensions, properties, or conditions may have some variation without significantly affecting functioning of systems, machines, structures, etc. A variation beyond the tolerance (for example, a temperature that's too hot or too cold) is said to be non-compliant, rejected, or exceeding the tolerance. If the tolerance is too restrictive, the machine being incapable of functioning in most environments, it is said to be intolerant.

Considerations when setting tolerances

Drug tolerance

Drug tolerance is a pharmacology concept where a subject's reaction to a specific drug and concentration of the drug is reduced followed repeated use, requiring an increase in concentration to achieve the desired effect.

The following are characteristics of drug tolerance: it is reversible, the rate depends on the particular drug, dosage and frequency of use, differential development occurs for different effects of the same drug.

Tachyphylaxis

Tachyphylaxis is a sudden onset drug tolerance which is not dose dependent.

Pharmacodynamic tolerance

Pharmacodynamic tolerance occurs when the cellular response to a substance is reduced with repeated use. This may be caused by a reduced receptor response to receptor agonists (receptor desensitization), a reduction in receptor density (usually associated with receptor agonists), or other mechanisms leading to changes in action potential firing rate. Pharmacodynamic tolerance to a receptor antagonist involves the reverse, i.e., increased receptor firing rate, an increase in receptor density, or other mechanisms.

Divin

Divin may refer to:

Divin, Bileća

Divin (Serbian Cyrillic: Дивин) is a village in the municipality of Bileća, Republika Srpska, Bosnia and Herzegovina.

References

Coordinates: 43°02′N 18°18′E / 43.033°N 18.300°E / 43.033; 18.300