Titin
Titin /ˈtaɪtɪn/, also known as connectin, is a protein that, in humans, is encoded by the TTN gene. Titin is a giant protein, greater than 1 µm in length, that functions as a molecular spring which is responsible for the passive elasticity of muscle. It is composed of 244 individually folded protein domains connected by unstructured peptide sequences. These domains unfold when the protein is stretched and refold when the tension is removed.
Titin is important in the contraction of striated muscle tissues. It connects the Z line to the M line in the sarcomere. The protein contributes to force transmission at the Z line and resting tension in the I band region. It limits the range of motion of the sarcomere in tension, thus contributing to the passive stiffness of muscle. Variations in the sequence of titin between different types of muscle (e.g., cardiac or skeletal) have been correlated with differences in the mechanical properties of these muscles.
After myosin and actin, titin is the third most abundant protein in muscle and an adult human contains approximately 0.5 kg of titin. With its length of ~27,000 to ~33,000 amino acids (depending on the splice isoform), titin is the largest known protein. Furthermore, the gene for titin contains the largest number of exons (363) discovered in any single gene, as well as the longest single exon (17,106 bp).
Podcasts:
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by Dayton
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by T. One
Super Swag
by: DaytonIntro:
Yeah (yeah)
I see em lookin
I see em lookin but can't do it like me (like me)
Hook:
I got a super stupid swag
N they like it so they biting on it
Super stupid swag
N they like it so they biting on it
You see my neck (you see my neck)
You see my wrist (you see my wrist)
You see my gear but u don't rock it like this (like this)
Verse 1:
Look up in the sky its bird it’s a plane
Naw it’s the flyest muthafucka in the game you know the name (u know the name)
I'm like the best that ever done it bitch
I be on my grizzy n I'm stuntin like I'm hella rich (rich)
But imma block boy
Whip it in a pot boy
N try to get it gone before I'm rushing from the cop’s boy
They see that Caddy or that LS lookin hot boy
N wonder how he got it did he steal it or them rocks boy (yea)
N my swagga keep them hataz on alert
Guz my game it'll take ya shawty right out of her skirt (like take that off)
N my level dawg is so out of this earth
I been sittin on the top ever since mama gave me birth (I love u ma)
N I be fresh it aint just a new shirt (naw)
It’s the jeans, it’s the shoes, n the fitted too jerk (ha-ha)
The way they staring all I can do is smirk
They so confused lookin like I guess he really do work
Verse 2:
Hit the club look now everybody’s eyes glued
All of them aint ballin but they lookin they try too
The bottles half off so that mean ill buy two
Bet u i'll be nice before we leavin here around 2
I got my hater blockers on they all around too
I hope nobody here step out of line guz imma pound you
Show how I get down dude
Leave u on the ground too
Or drag yo ass right out of the club just for round 2
We shut the building every time we go up in it
10 to 20 deep or more every time we go up in it
Came here for show so u know I’m bout to handle business
They way I does it they be hoping that I never finish
Like I’m the best so throw ya hands up if u feel u winning
Gettin money swagga crazy throw ya hands up if u winning
Shinning bright, ya game is right, man throw ya hands up if u winning
Cant nobody top u man look throw ya hands up if u winning
Verse 3:
Man I’m the boss type
You could be the worker
I just pitch u out a deal like I marketer or broker
We talking stocks n bonds but the product aint commercial
If they know u got it n they want it then they'll probably hurt u (probably hurt u)
I live a fast life u could call it NASCAR
I bring the jungle to the city like its Madagascar
But this aint animated lookin through the glass yall
That lion coming at u it'll bite u in the ass boy
Just look around dawg my city is a mess
But to me and most others here thinking it’s the best (it’s the best)
I got full time grind no rest
N my swag that’s a full time shine no rest
Yall thinking its money or ya whips or ya jewels
Naw it’s all about cha class thought they taught em that in school
If u aint have it back then u better try to get it now
Man I always had it in me so I just look up n smile (I got a)