Tir (month)
Tir (Persian: تیر, Persian pronunciation: [tiːɾ]) is the fourth month of the Iranian calendar. It begins in June and ends in July of the Gregorian calendar. Tir has thirty-one days, spanning June and July in the Gregorian calendar.
Tir is the first month of summer, and is followed by Mordad.
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TIR
Tir, tir or TIR may mean:
Abbreviations
Tir (receptor)
Tir (translocated intimin receptor) is an essential component in the adherence of the enteropathogenic Escherichia coli (EPEC) and enterohemorraghic Escherichia coli to the cells lining the small intestine. To aid attachment, both EPEC and EHEC possess the ability to reorganise the host cell actin cytoskeleton via the secretion of virulence factors. These factors are secreted directly into the cells using a Type three secretion system. One of the virulence factors secreted is the Translocated Intimin Receptor (Tir). Tir is a receptor protein encoded by the espE gene which is located on the locus of enterocyte effacement (LEE) pathogenicity island in EPEC strains. It is secreted into the host cell membranes and acts as a receptor for intimin which is found on the bacterial surface. Once Tir binds intimin, the bacterium is attached to the enterocyte surface.
Tir is also a receptor tyrosine kinase (RTK) that initiates its intimate adherence by inserting a hairpin orientation in the intestinal cell membrane to enable tight binding to intimin on the bacterial cell outer membrane. Upon phosphorylation, Tir activates condensation and polymerization of actin filaments under the bacterial cell to form a pedestal-like structure.
Iran student protests, July 1999
Iranian Student Protests of July, 1999 (Also known as 18th of Tir and Kuye Daneshgah Disaster (Persian: فاجعه کوی دانشگاه) in Iran) (7–13 July) were, before the 2009 Iranian election protests, the most widespread and violent public protests to occur in Iran since the early years of the Iranian Revolution.
The protests began on 8 July with peaceful demonstrations in Tehran against the closure of the reformist newspaper, Salam. Following the demonstrations, a student dormitory was raided by riot police that night during which a student was killed. The raid sparked six days of demonstrations and rioting throughout the country, during which at least three other people were killed and more than 200 injured.
In the aftermath of these incidents, more than seventy students disappeared. In addition to an estimated 1,200–1,400 detainees, the "whereabouts and condition" of five students named by Human Rights Watch who are believed to be detained by Islamic authorities remain unknown.
