Terbequinil

Terbequinil

Systematic (IUPAC) name
1-(methoxymethyl)-4-oxo-N-propylquinoline-3-carboxamide
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	113079-82-6
ATC code	None
PubChem	CID 65916
ChemSpider	59325^Y
UNII	0DH9WUS03O^Y
Chemical data
Formula	C₁₅H₁₈N₂O₃
Mol. mass	274.315 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C15H18N2O3/c1-3-8-16-15(19)12-9-17(10-20-2)13-7-5-4-6-11(13)14(12)18/h4-7,9H,3,8,10H2,1-2H3,(H,16,19)^Y Key:RIPDGZHPNKQLDC-UHFFFAOYSA-N^Y
Y (what is this?) (verify)

Terbequinil (SR-25776) is a stimulant and nootropic drug which acts as a partial inverse agonist at benzodiazepine sites on the GABA_A receptor. In human trials it was found to partially reverse the sedative and amnestic effects of the hypnotic drug triazolam with only slight effects when administered by itself.^[1]

References [link]

^ Warot D, Danjou P, Douillet P, Keane P, Puech AJ. Cognitive impairments induced by triazolam in healthy volunteers: antagonism by a partial inverse agonist of benzodiazepine receptor. Therapie. 1994 Jan-Feb;49(1):23-6. PMID 8091361

v t e Nootropics (N06B)

Acetylcholinesterases	Donepezil Galantamine Huperzine A (Huperzia Serrata) Ladostigil Rivastigmine Tacrine

Ampakines	CX-516 CX-546 CX-614 CX-691 CX-717 IDRA-21 LY-404,187 LY-503,430 PEPA Sunifiram Unifiram

D₁ Agonists	6-Br-APB A-77636 Dihydrexidine Dinapsoline Doxanthrine SKF-81297

Eugeroics	Adrafinil Armodafinil Modafinil

GABA_A α₅ Inverse Agonists	α5IA L-655,708 PWZ-029 Suritozole TB-21007 ZK-93426

H₃ Antagonists	A-349,821 ABT-239 Ciproxifan GSK-189,254

mACh Agonists	Alvameline Arecoline Cevimeline CI-1017 Milameline Sabcomeline Talsaclidine Tazomeline Xanomeline

nACh Agonists	AR-R17779 Ispronicline Nicotine PNU-282,987 SSR-180,711 WAY-317,538

Racetams	Aniracetam Brivaracetam Coluracetam Etiracetam Fasoracetam Levetiracetam Nebracetam Nefiracetam Oxiracetam Phenylpiracetam Piracetam Pramiracetam Rolziracetam Seletracetam

Others	Acetylcarnitine Adafenoxate Bifemelane Bilobalide (Ginkgo Biloba) Carbenoxolone Cerlapirdine Choline (Lecithin) Citicoline Cyprodenate Dimethylethanolamine Ensaculin Fipexide Idebenone Indeloxazine Latrepirdine Leteprinim Linopirdine Meclofenoxate Nizofenone Pirisudanol Pyritinol S-17092 Sulbutiamine Taltirelin Teniloxazine Tricyanoaminopropene Vinpocetine

GABAergics

Receptor
ligands

GABA_A	Agonists: Main site: Bamaluzole Gaboxadol Ibotenic acid Isoguvacine Isonipecotic acid Muscimol (Amanita Muscaria) Progabide SL 75102 Thiomuscimol Tolgabide; Positive allosteric modulators: Barbiturates Benzodiazepines Carbamates Chlormezanone Clomethiazole Ethanol (Alcohol) Etomidate Kavalactones (Kava) Loreclezole Metomidate Neuroactive steroids Nonbenzodiazepines (β-Carbolines, Cyclopyrrolones, Imidazopyridines, Pyrazolopyrimidines, etc.) Phenols Piperidinediones Propanidid Pyrazolopyridines Quinazolinones ROD-188 Skullcap Stiripentol Valerenic acid (Valerian) Note: See the GABA_A receptor PAMs navbox for a full list of GABA_A positive allosteric modulators. Antagonists: Main site: Bicuculline Gabazine Pitrazepin Quisqualamine; Negative allosteric modulators: α5IA Bilobalide Cicutoxin Cyclothiazide DMCM Flumazenil Flurothyl Furosemide Iomazenil (¹²³I) L-655,708 Oenanthotoxin Penicillin Pentylenetetrazol Picrotoxin PWZ-029 Radequinil Ro15-4513 Sarmazenil Suritozole Terbequinil Thujone Thiocolchicoside ZK-93426

GABA_B	Agonists: Main site: 1,4-Butanediol Baclofen GBL GHB GHV GVL Lesogaberan Phenibut Progabide SKF-97,541 Tolgabide; Positive allosteric modulators: BHF-177 BHFF BSPP CGP-7930 GS-39783 Antagonists: Main site: CGP-35348 Phaclofen Saclofen SCH-50911

GABA_C	Agonists: Main site: CACA CAMP GABOB N⁴-Chloroacetylcytosine arabinoside Progabide Tolgabide Antagonists: Main site: Bilobalide TPMPA

Reuptake
inhibitors

Plasmalemmal

GAT inhibitors	CI-966 Deramciclane EF-1502 Gabaculine Guvacine Nipecotic acid NNC 05-2090 SKF-89976A SNAP-5114 Tiagabine

Enzyme
inhibitors

Anabolism

GAD inhibitors	Allylglycine

Catabolism

GABA-T inhibitors	3-Hydrazinopropionic acid Aminooxyacetic acid Gabaculine Isoniazid Phenelzine Phenylethylidenehydrazine Sodium valproate Valnoctamide Valproate pivoxil Valproate semisodium (Divalproex sodium) Valproic acid Valpromide Vigabatrin

Others

Precursors	Glutamate Glutamine

Cofactors	Vitamin B6 (pyridoxine pyridoxamine pyridoxal phosphate)

Others	Gabapentin L-Theanine Picamilon Pregabalin

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References [link]

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