Terazosin
Terazosin (marketed as Hytrin or Zayasel) is a selective alpha-1 antagonist used for treatment of symptoms of an enlarged prostate (BPH). It also acts to lower the blood pressure, and is therefore a drug of choice for men with hypertension and prostate enlargement. It is available in 1 mg, 2 mg, 5 mg or 10 mg doses.
It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls.
Most common side effects include dizziness, drowsiness, headache, constipation, loss of appetite, fatigue, nasal congestion or dry eyes, but they generally go away after only a few days of use. Therapy should always be started with a low dose to avoid first dose phenomenon. Sexual side effects are rare, but may include priapism or erectile dysfunction.
Synthesis
Reaction of piperazine with 2-furoyl chloride followed by catalytic hydrogenation of the furan ring leads to 2. This, when heated in the presence of 2-chloro-6,7-dimethoxyquinazolin-4-amine (1) undergoes direct alkylation to terazocin (3).
Podcasts:
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by Bee Gees
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by The Bee Gees
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by Justin Timberlake
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by Space
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by Justin Moore
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by Terry Macalmon
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by Chris Turner
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by Eugene Wilde
Two Years On
by: Bee GeesOne year, two years, time goes by.
People laugh and people cry.
Ev'ry morning the clock strikes eight.
I go to work. I close the gate.
And on my way, I sing a song.
About my wife, where I belong.
If the clouds get together and talk about the weather
If it's rain they anticipate
Baby make no mistake
Yes the storm will break but never me you see.
Two years on . Two years on .
But only you can see me.
Only you can see me.
For what I've got
Sir Lancelot was just a dream and I am not
For I am he with something more
It's you and I reality.
If the cloud get together and talk about the weather
If it's rain they anticipate
Baby, make no mistake
Yes the storm will break but never me you see
Two years on . Two years on .
But only you can see me
Only you can see me
Two years on . Two years on .