Tubulin folding cofactor D
Identifiers
Symbols TBCD; KIAA0988
External IDs OMIM604649 MGI1919686 HomoloGene4368 GeneCards: TBCD Gene
RNA expression pattern
PBB GE TBCD 201759 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6904 108903
Ensembl ENSG00000141556 ENSMUSG00000039230
UniProt Q9BTW9 Q8BYA0
RefSeq (mRNA) NM_001033052.1 NM_029878.3
RefSeq (protein) NP_005984.3 NP_084154.1
Location (UCSC) Chr 17:
80.71 – 80.91 Mb
Chr 11:
121.31 – 121.48 Mb
PubMed search [1] [2]

Tubulin-specific chaperone D is a protein that in humans is encoded by the TBCD gene.[1]

Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state.[1]

Interactions [link]

TBCD has been shown to interact with ARL2.[2][3]

References [link]

  1. ^ a b "Entrez Gene: TBCD tubulin folding cofactor D". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6904. 
  2. ^ Shern, Jack F; Sharer J Daniel, Pallas David C, Bartolini Francesca, Cowan Nicholas J, Reed Matthew S, Pohl Jan, Kahn Richard A (October 2003). "Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A". J. Biol. Chem. (United States) 278 (42): 40829–36. DOI:10.1074/jbc.M308678200. ISSN 0021-9258. PMID 12912990. 
  3. ^ Bhamidipati, A; Lewis S A, Cowan N J (May. 2000). "ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin". J. Cell Biol. (UNITED STATES) 149 (5): 1087–96. DOI:10.1083/jcb.149.5.1087. ISSN 0021-9525. PMC 2174823. PMID 10831612. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2174823. 

Further reading [link]




https://wn.com/TBCD

Binary-coded decimal

In computing and electronic systems, binary-coded decimal (BCD) is a class of binary encodings of decimal numbers where each decimal digit is represented by a fixed number of bits, usually four or eight. Special bit patterns are sometimes used for a sign or for other indications (e.g., error or overflow).

In byte-oriented systems (i.e. most modern computers), the term unpacked BCD usually implies a full byte for each digit (often including a sign), whereas packed BCD typically encodes two decimal digits within a single byte by taking advantage of the fact that four bits are enough to represent the range 0 to 9. The precise 4-bit encoding may vary however, for technical reasons, see Excess-3 for instance. The ten states representing a BCD decimal digit are sometimes called tetrades (for the nibble typically needed to hold them also known as tetrade) with those don't care-states unused named pseudo-tetrad(e)s or pseudo-decimal digit).

BCD's main virtue is its more accurate representation and rounding of decimal quantities as well as an ease of conversion into human-readable representations, in comparison to binary positional systems. BCD's principal drawbacks are a small increase in the complexity of the circuits needed to implement basic arithmetics and a slightly less dense storage.

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I got stoned this morning but I haven't had a drink all day




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