Tazarotene
Tazarotene (marketed as Tazorac, Avage, Zorac, and Fabior) is a third-generation prescription topical retinoid sold as a cream, gel, or foam. Tazarotene is a member of the acetylenic class of retinoids. This medication is approved for treatment of psoriasis, acne, and sun damaged skin (photodamage). It is commonly sold in two concentrations: 0.05% and 0.1%.
Mechanism of action
Tazarotene is a retinoid prodrug which is converted to its active form, the cognate carboxylic acid of tazarotene, by rapid deesterification in animals and humans. Tazarotenic acid binds to all three members of the retinoic acid receptor (RAR) family: RARα, RARβ, and RARγ but shows relative selectivity for RARβ, and RARγ and may modify gene expression. The clinical significance of these findings is unknown.
Side effects
Common side effects include worsening of acne, increased sensitivity to sunlight, dry skin, itchiness, redness and in some cases extreme drying and cracking of skin. For most patients these side effects are uncomfortable but mild and decrease markedly after the first 2–4 weeks of use except for increased sensitivity to sunlight.
Podcasts:
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by Delta
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by Izal
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by When Nothing Remains
Desire Within
by: DeltaBlack lady come to me
I want to go astray
Desire within me
A guide to my decay
I know that you’ll be gone
When night becomes a day
You yawned when I claimed love
Turned back and walked away
I call out your name
With no reply at all
Another pawn in your game
Meets his darkest fall
I’ve lost all my faith
My soul goes into stall
Maybe I am the eighth
That knocks at your back door
I want to feel again
That pleasant strawberry haze
Maybe I’ve gone insane
The devil’s dancer caught me
Enticed me, and fooled me
Again and again and again
Into the night she comes
And suddenly she strikes
Another fool has fallen into her
And when the time is right
She leaves you far behind
Desperation feeling in your mind
I want to feel again
That pleasant strawberry haze
Maybe I’ve gone insane
The devil’s dancer caught me
Why don’t you dance all night?
Let’s step out of the light
Entice me, and fool me
Again and again and again
I want to feel again
That pleasant strawberry haze
Maybe I’ve gone insane
The devil’s dancer caught me
Why don’t you dance all night?
Let’s step out of the light
I wan to feel alright
The devil’s dancer caught me
Enticed me, fooled me