Taste receptor type 2 member 4 is a protein that in humans is encoded by the TAS2R4 gene.[1][2][3]
This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception.[3]
- ^ Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (Apr 2000). "A novel family of mammalian taste receptors". Cell 100 (6): 693–702. DOI:10.1016/S0092-8674(00)80705-9. PMID 10761934.
- ^ Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ (Apr 2000). "T2Rs function as bitter taste receptors". Cell 100 (6): 703–11. DOI:10.1016/S0092-8674(00)80706-0. PMID 10761935.
- ^ a b "Entrez Gene: TAS2R4 taste receptor, type 2, member 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50832.
- Kinnamon SC (2000). "A plethora of taste receptors". Neuron 25 (3): 507–10. DOI:10.1016/S0896-6273(00)81054-5. PMID 10774719.
- Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction". J. Biol. Chem. 277 (1): 1–4. DOI:10.1074/jbc.R100054200. PMID 11696554.
- Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol. 12 (4): 366–71. DOI:10.1016/S0959-4388(02)00345-8. PMID 12139982.
- Firestein S (2000). "The good taste of genomics". Nature 404 (6778): 552–3. DOI:10.1038/35007167. PMID 10766221.
- Matsunami H, Montmayeur JP, Buck LB (2000). "A family of candidate taste receptors in human and mouse". Nature 404 (6778): 601–4. DOI:10.1038/35007072. PMID 10766242.
- Ueda T, Ugawa S, Ishida Y et al. (2001). "Identification of coding single-nucleotide polymorphisms in human taste receptor genes involving bitter tasting". Biochem. Biophys. Res. Commun. 285 (1): 147–51. DOI:10.1006/bbrc.2001.5136. PMID 11437385.
- Zhang Y, Hoon MA, Chandrashekar J et al. (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell 112 (3): 293–301. DOI:10.1016/S0092-8674(03)00071-0. PMID 12581520.
- Hillier LW, Fulton RS, Fulton LA et al. (2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. DOI:10.1038/nature01782. PMID 12853948.
- Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes". Mol. Biol. Evol. 22 (3): 432–6. DOI:10.1093/molbev/msi027. PMID 15496549.
- Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates". Genetics 170 (1): 313–26. DOI:10.1534/genetics.104.037523. PMC 1449719. PMID 15744053. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1449719.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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Class A:
Rhodopsin like |
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Metabolites and
signaling molecules
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Peptide
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Miscellaneous
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Class B: Secretin like |
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Class C: Metabotropic
glutamate / pheromone |
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Class F:
Frizzled / Smoothened |
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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