Talin

Talin may refer to:

Places

Armenia

Estonia

Iran

Syria

Other

See also

Talin protein

Talin is a high-molecular-weight cytoskeletal protein concentrated at regions of cell–substratum contact and, in lymphocytes, at cell–cell contacts. Discovered in 1983 by Keith Burridge and colleagues, talin is a ubiquitous cytosolic protein that is found in high concentrations in focal adhesions. It is capable of linking integrins to the actin cytoskeleton either directly or indirectly by interacting with vinculin and alpha-actinin.

Integrin receptors are involved in the attachment of adherent cells to the extracellular matrix and of lymphocytes to other cells. In these situations, talin codistributes with concentrations of integrins in the plasma membrane. Furthermore, in vitro binding studies suggest that integrins bind to talin, although with low affinity. Talin also binds with high affinity to vinculin, another cytoskeletal protein concentrated at points of cell adhesion. Finally, talin is a substrate for the calcium-ion activated protease, calpain II, which is also concentrated at points of cell–substratum contact.

Talin (Verin Talin)

Coordinates: 40°22′56″N 43°52′43″E / 40.38222°N 43.87861°E / 40.38222; 43.87861

Talin (also, T’alin, Verin Talin, and Verkhniy Talin) is a town in the Aragatsotn Province of Armenia.

References