Transcriptional adapter 3-like is a protein that in humans is encoded by the TADA3 gene.[1][2][3]
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. In addition, it associates with the tumor suppressor protein p53 and is required for full activity of p53 and p53-mediated apoptosis. At least four alternatively spliced variants have been found for this gene, but the full-length nature of some variants has not been determined.[3]
Interactions [link]
TADA3L has been shown to interact with Retinoic acid receptor alpha,[4] USP5,[5] TAF9,[6] Transcription initiation protein SPT3 homolog,[6] TADA2L[2][5] and Retinoid X receptor alpha.[4]
References [link]
- ^ Ogryzko VV, Kotani T, Zhang X, Schiltz RL, Howard T, Yang XJ, Howard BH, Qin J, Nakatani Y (August 1998). "Histone-like TAFs within the PCAF histone acetylase complex". Cell 94 (1): 35–44. DOI:10.1016/S0092-8674(00)81219-2. PMID 9674425.
- ^ a b Wang T, Kobayashi T, Takimoto R, Denes AE, Snyder EL, el-Deiry WS, Brachmann RK (November 2001). "hADA3 is required for p53 activity". EMBO J 20 (22): 6404–13. DOI:10.1093/emboj/20.22.6404. PMC 125723. PMID 11707411. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125723.
- ^ a b "Entrez Gene: TADA3L transcriptional adaptor 3 (NGG1 homolog, yeast)-like". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10474.
- ^ a b Zeng, Musheng; Kumar Ajay, Meng Gaoyuan, Gao Qingshen, Dimri Goberdhan, Wazer David, Band Hamid, Band Vimla (November 2002). "Human papilloma virus 16 E6 oncoprotein inhibits retinoic X receptor-mediated transactivation by targeting human ADA3 coactivator". J. Biol. Chem. (United States) 277 (47): 45611–8. DOI:10.1074/jbc.M208447200. ISSN 0021-9258. PMID 12235159.
- ^ a b Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514.
- ^ a b Martinez, E; Palhan V B, Tjernberg A, Lymar E S, Gamper A M, Kundu T K, Chait B T, Roeder R G (October 2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Mol. Cell. Biol. (United States) 21 (20): 6782–95. DOI:10.1128/MCB.21.20.6782-6795.2001. ISSN 0270-7306. PMC 99856. PMID 11564863. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=99856.
Further reading [link]
- Struhl K, Moqtaderi Z (1998). "The TAFs in the HAT". Cell 94 (1): 1–4. DOI:10.1016/S0092-8674(00)81213-1. PMID 9674419.
- Brand M, Yamamoto K, Staub A, Tora L (1999). "Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction". J. Biol. Chem. 274 (26): 18285–9. DOI:10.1074/jbc.274.26.18285. PMID 10373431.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. DOI:10.1101/gr.143000. PMC 310948. PMID 11076863. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. DOI:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072.
- Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. DOI:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1083732.
- Brand M, Moggs JG, Oulad-Abdelghani M, et al. (2001). "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation". EMBO J. 20 (12): 3187–96. DOI:10.1093/emboj/20.12.3187. PMC 150203. PMID 11406595. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=150203.
- Martinez E, Palhan VB, Tjernberg A, et al. (2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Mol. Cell. Biol. 21 (20): 6782–95. DOI:10.1128/MCB.21.20.6782-6795.2001. PMC 99856. PMID 11564863. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=99856.
- Benecke A, Gaudon C, Garnier JM, et al. (2002). "ADA3-containing complexes associate with estrogen receptor alpha". Nucleic Acids Res. 30 (11): 2508–14. DOI:10.1093/nar/30.11.2508. PMC 117179. PMID 12034840. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=117179.
- Kumar A, Zhao Y, Meng G, et al. (2002). "Human papillomavirus oncoprotein E6 inactivates the transcriptional coactivator human ADA3". Mol. Cell. Biol. 22 (16): 5801–12. DOI:10.1128/MCB.22.16.5801-5812.2002. PMC 133989. PMID 12138191. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=133989.
- Zeng M, Kumar A, Meng G, et al. (2003). "Human papilloma virus 16 E6 oncoprotein inhibits retinoic X receptor-mediated transactivation by targeting human ADA3 coactivator". J. Biol. Chem. 277 (47): 45611–8. DOI:10.1074/jbc.M208447200. PMID 12235159.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
- Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell 15 (6): 853–65. DOI:10.1016/j.molcel.2004.09.016. PMID 15383276.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. DOI:10.1101/gr.2576704. PMC 528930. PMID 15489336. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528930.
- Meng G, Zhao Y, Nag A, et al. (2005). "Human ADA3 binds to estrogen receptor (ER) and functions as a coactivator for ER-mediated transactivation". J. Biol. Chem. 279 (52): 54230–40. DOI:10.1074/jbc.M404482200. PMID 15496419.
- Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. DOI:10.1016/j.cell.2005.08.029. PMID 16169070.
 |
This article on a gene on chromosome 3 is a stub. You can help Wikipedia by expanding it. |
https://wn.com/TADA3L
Podcasts:
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by Total
-
by D4L
-
by D4L
-
by D4L
-
by D4L
-
by D4L
-
by D4L
-
by D4L
-
by D4L
-
by D4L
-
by D4L
-
by D4L
-
by D4L
Bring Home Da Bacon
by: TotalRap (indo g):
Now c'mon and tear da club up,
Toss and floss 100,
Even if you don't want it,
But if ya got it flaunt it.
Angeldust get the jail break,
What the cuff locked up.
Snakes can slither like robbers into a bank,
My idea of a joke is no high school prank.
Call me on da phone and see what ya want,
Cause my three 6 mafia presents world domination.
Verse one (keisha):
Couldn't alwayz pay ya back,
Because I knew you would go buy crack.
I can't believe that he dropped me,
But now I know ya got me ohhhh.
Chorus (total and three 6 mafia):
Couldn't bring home the bacon,
Prepare for a world domination.
Couldn't bring home the bacon,
Prepare for world domination.
Verse 2 (kima):
Hey baby before we get in the mood,
What kind of work do you do?
Can ya bring home the bacon,
Or must I do it?
(pam)
Only you know about what you say boy,
Can you bring home the bacon or what?
Ohhhhh
Repeat chorus
Rap (gangsta boo):
Ready to tell you all,
That I like to ball take me to the mall?
Bring home the bacon cause satisfaction is waiting,
Anticipation can chill wit cream,
And still play it all mean.
Take it to the wrist the ice and the diamonds,
We can do the french kiss once I know what your about,
There can be a miracle when you believe,
Because I ride in a b-e-n-t-l-e but y?