Tyrosine kinase 2
Non-receptor tyrosine-protein kinase TYK2 is an enzyme that in humans is encoded by the TYK2 gene.
Tyk2 was the first member of the JAK family that was described (the other members are JAK1, JAK2, and JAK3). It has been implicated in IFN-α, IL-6, IL-10 and IL-12 signaling.
Function
This gene encodes a member of the tyrosine kinase and, to be more specific, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity.
Cytokines play pivotal roles in immunity and inflammation by regulating the survival, proliferation, differentiation, and function of immune cells, as well as cells from other organ systems. Hence, targeting cytokines and their receptors is an effective means of treating such disorders. Type I and II cytokine receptors associate with Janus family kinases (JAKs) to effect intracellular signaling. Cytokines including interleukins, interferons and hemopoietins activate the Janus kinases, which associate with their cognate receptors.
Podcasts:
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by TG4
Virginity
by: TG4I know you want it
You wanna hit it
But you can't have it
Oops, can't touch it
Maybe a kiss on these lips
Holding hands it aint nothing
Nasty is what you call me
We get close but you can't handle it
Cuz I'm not maybe what your looking
Cuz I'm not the average kind of girl
I might let you touch me
I might let you hold me
I might even let you kiss me
But you can not take my virginity
I might let you tease me
I might let you squeeze me
I might even let you kiss me
But you can not take my virginity
Can't imagine what it feels like
My friends say it's alright
But then they go and do it all night
But I prefer the merry life
Patience is what you gotta have
That's what it takes to be my man
I'm not like that bad if you like me
Keep it with you then maybe
I might let you touch me
I might let you hold me
I might even let you kiss me
But you can not take my virginity
I might let you tease me
I might let you squeeze me
I might even let you kiss me
But you can not take my virginity
Baby its not like I dont really like you
You just gotta know
That if your not willing to get with my loving
Than you've gotta go
Baby its not like I dont really like you
You just gotta know
That if your not willing to get with my loving
Than you've gotta go
God D@^^* what part don't you understand
The N or the O
You get nothing from TG4
Let it go
Here we go
With the everyday scenario
Jeans painted on cleavage showin
Dont mean she easy
Girl you gotta keep your integrity
I wouldn't let him get over on me
Dont fall for the same game
Him callin you boo
Telling you he love you
And everything he gone do
Treat your body like a temple
The best thing ever made
Cuz once you let him hit
Watch how those feelings fade away
You gotta be the best at this game being played
Dont give it up know
Some things are better off saved
I might let you touch me
I might let you hold me
I might even let you kiss me
But you can not take my virginity
I might let you tease me
I might let you squeeze me
I might even let you kiss me
But you can not take my virginity
I might let you touch me
I might let you hold me
I might even let you kiss me
But you can not take my virginity
I might let you tease me
I might let you squeeze me
I might even let you kiss me
But you can not take my virginity
I might let you touch me
I might let you hold me
I might even let you kiss me
But you can not take my virginity
I might let you tease me
I might let you squeeze me
I might even let you kiss me