TTC7A
Tetratricopeptide repeat domain 7A (TTC7A) is a protein that in humans is encoded by the TTC7A gene.
Function
TPR domain-containing proteins, such as TTC7A, have diverse functions in cell cycle control, protein transport, phosphate turnover, and protein trafficking or secretion, and they can act as chaperones or scaffolding proteins.
Clinical significance
Mutations in this gene are known to cause hereditary multiple intestinal atresia (MIA), severe infantile or very early onset Inflammatory Bowel Disease, extensive enteropathy, and combined immunodeficiencies (CID).
TTC7A Deficiency may also cause lung disease.
Quality of life is generally very poor and few children survive beyond the first year or two of life. However, there is a broad spectrum of severity of symptoms varying from individual to individual with some forms of TTC7A Deficiency being less severe.
Treatment of TTC7A Deficiency
There is no standard treatment for TTC7A Deficiency at this time. Management of TTC7A deficiency currently entails bowel resection for any atresias, possibly hematopoietic stem cell transplantation to correct the immunodeficiencies, and immunosuppression to help alleviate bowel disease and immune disregulation. Small bowel transplant has proven successful in at least one case.
Podcasts:
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by TG4
Virginity
by: TG4I know you want it
You wanna hit it
But you can't have it
Oops, can't touch it
Maybe a kiss on these lips
Holding hands it aint nothing
Nasty is what you call me
We get close but you can't handle it
Cuz I'm not maybe what your looking
Cuz I'm not the average kind of girl
I might let you touch me
I might let you hold me
I might even let you kiss me
But you can not take my virginity
I might let you tease me
I might let you squeeze me
I might even let you kiss me
But you can not take my virginity
Can't imagine what it feels like
My friends say it's alright
But then they go and do it all night
But I prefer the merry life
Patience is what you gotta have
That's what it takes to be my man
I'm not like that bad if you like me
Keep it with you then maybe
I might let you touch me
I might let you hold me
I might even let you kiss me
But you can not take my virginity
I might let you tease me
I might let you squeeze me
I might even let you kiss me
But you can not take my virginity
Baby its not like I dont really like you
You just gotta know
That if your not willing to get with my loving
Than you've gotta go
Baby its not like I dont really like you
You just gotta know
That if your not willing to get with my loving
Than you've gotta go
God D@^^* what part don't you understand
The N or the O
You get nothing from TG4
Let it go
Here we go
With the everyday scenario
Jeans painted on cleavage showin
Dont mean she easy
Girl you gotta keep your integrity
I wouldn't let him get over on me
Dont fall for the same game
Him callin you boo
Telling you he love you
And everything he gone do
Treat your body like a temple
The best thing ever made
Cuz once you let him hit
Watch how those feelings fade away
You gotta be the best at this game being played
Dont give it up know
Some things are better off saved
I might let you touch me
I might let you hold me
I might even let you kiss me
But you can not take my virginity
I might let you tease me
I might let you squeeze me
I might even let you kiss me
But you can not take my virginity
I might let you touch me
I might let you hold me
I might even let you kiss me
But you can not take my virginity
I might let you tease me
I might let you squeeze me
I might even let you kiss me
But you can not take my virginity
I might let you touch me
I might let you hold me
I might even let you kiss me
But you can not take my virginity
I might let you tease me
I might let you squeeze me
I might even let you kiss me