TSC2

Tuberous Sclerosis Complex 2 (TSC2), also known as Tuberin, is a protein that in humans is encoded by the TSC2 gene.

Function

Mutations in this gene lead to tuberous sclerosis. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms of the protein. Together with tuberous sclerosis, mutations in TSC2 can cause Lymphangioleiomyomatosis, a disease caused by the enlargement of tissue in the lungs, creating cysts and tumours and causing difficulty breathing. Because Tuberin regulates cell size, along with the protein Hamartin coded by the gene TSC1, mutations to these genes may prevent the control of cell growth in the lungs of individuals.

Interactions

TSC2 functions within a multi-protein complex knowns as the TSC complex which consists of the core proteins TSC2, TSC1, and TBC1D7.

Interaction

Interaction is a kind of action that occurs as two or more objects have an effect upon one another. The idea of a two-way effect is essential in the concept of interaction, as opposed to a one-way causal effect. A closely related term is interconnectivity, which deals with the interactions of interactions within systems: combinations of many simple interactions can lead to surprising emergent phenomena. Interaction has different tailored meanings in various sciences. Changes can also involve interaction.

Casual examples of interaction outside science include:

Interactions (The Spectacular Spider-Man)

"Interactions" is the second episode of the animated television series The Spectacular Spider-Man, based on the comic book character Spider-Man created by Stan Lee and Steve Ditko. The episode sees Spider-Man confronting the supervillain Electro, whose body was corrupted with electricity after a freak lab accident.

Directed by Troy Adomitis, "Interactions" was written by Kevin Hopps, who researched all the available comic books he had that featured Electro. The character's appearance in the episode draws on his traditional comic book style, though designer Victor Cook emphasized the color green and removed the character's customary star-shaped mask. His voice actor, Crispin Freeman, sought to reflect the character's declining sanity in his vocal style.

"Interactions" first aired March 8, 2008, on the Kids' WB block of The CW network, following the first episode. Its 1.4/4 Nielsen rating was higher than that of the pilot, "Survival of the Fittest". The episode received mixed reviews; IGN commented that "[w]hile not as strong as the pilot, the episode had some notable moments".

ACM Interactions

ACM interactions magazine serves a number of related worlds, offering content to educate and inspire designers, providing viewpoints related to culture and anthropology, describing innovation and creation in a business environment, and continually investigating the relationship between people, experiences, and technology. Its publisher is ACM and the headquarters is in New York City.

History

First published in 1994, interactions initially appeared quarterly but moved to bi-monthly in 1996. Since 2000, SIGCHI -- ACM's Special Interest Group on Computer Human Interaction -- has included a subscription to interactions among its benefits of membership.

ACM interactions is the third largest ACM publication, and receives the second most citations, according to an article by new editors Wakkary and Stolterman in SIGCHI 2011.

Structure

Each issue contains a cover story, regarded as the keynote article. Forums are published three times a year by specific Forum Editors, contributing a perspective such as sustainability or public policy. Blogspots are opinionated personal pieces, The Demo Hour segments represent a glimpse at a specific project, and Day in the Lab articles feature labs across the globe.