TRPV5

Transient receptor potential cation channel subfamily V member 5 is a protein that in humans is encoded by the TRPV5 gene.

TRPV5 is mainly expressed in kidney epithelial cells, where it plays an important role in the reabsorption of Ca²⁺. Genetic deletion of TRPV5 in mice leads to Ca²⁺ loss in the urine, and consequentual hyperparathyroidism, and bone loss.

Function

This gene is a member of the transient receptor family and the TRPV subfamily. The calcium-selective channel , TRPV5, encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level.

Interactions

TRPV5 has been shown to interact with S100A10.

See also

References

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.