The short transient receptor potential channel 4 (TrpC4), also known as Trp-related protein 4, is a protein that in humans is encoded by the TRPC4 gene.
TrpC4 is a member of the transient receptor potential cation channels. This protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation.
The nonselective cation channel TrpC4 has been shown to be present in high abundance in the cortico-limbic regions of the brain. In addition, TRPC4 mRNA is present in midbrain dopaminergic neurons in the ventral tegmental area and the substantia nigra.
Deletion of the trpc4 gene decreases levels of sociability in a social exploration task. These results suggest that TRPC4 may play a role in regulating social anxiety in a number of different disorders. However deletion of the trpc4 gene had no impact on basic or complex strategic learning. Given that the trpc4 gene is expressed in a select population of midbrain dopamine neurons it has been proposed that is may have an important role in dopamine related processes including addiction and attention.
Transient receptor potential cation channel, subfamily C, member 6, also known as TRPC6, is a human gene encoding a protein of the same name. TRPC6 is a transient receptor potential ion channel. It has been associated with depression and anxiety (see below), as well as with focal segmental glomerulosclerosis (FSGS).
TRPC6 has been shown to interact with:
Two of the primary active constituents responsible for the antidepressant and anxiolytic benefits of Hypericum perforatum, also known as St. John's Wort, are hyperforin and adhyperforin. These compounds are inhibitors of the reuptake of serotonin, norepinephrine ,dopamine, γ-aminobutyric acid, and glutamate, and they exert these effects by binding to and activating TRPC6. Activation of TRPC6 induces the entry of Ca2+ and Na+ into the cell, which results in the inhibition of reuptake.
Transient receptor potential cation channel, subfamily C, member 2, also known as TRPC2, is a protein that in humans is encoded by the TRPC2 pseudogene. This protein is not expressed in humans but is in certain other species such as mouse.
TRPC2 has been shown to interact with TRPC6.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
That's the dark side of obediance
That's the dark side of obediance
When somebody tied my poor dog up
I found that I was totally stuck
I'd trained him not to let out a yelp
That's why he didn't get any help
Nobody came to help in October
Nobody came to help in November
My dog was praiseworthy quiet and sober
So nobody came to help in December
So he laid down now on the doorstep and died
And I'm still sitting here all tied up inside
That's the dark side of obediance