| Tripartite motif containing 29 | |||||||||||||
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 PDB rendering based on 2csv. |
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| Identifiers | |||||||||||||
| Symbols | TRIM29; ATDC | ||||||||||||
| External IDs | OMIM: 610658 HomoloGene: 8100 GeneCards: TRIM29 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 23650 | n/a | |||||||||||
| Ensembl | ENSG00000137699 | n/a | |||||||||||
| UniProt | Q14134 | n/a | |||||||||||
| RefSeq (mRNA) | NM_012101.3 | n/a | |||||||||||
| RefSeq (protein) | NP_036233.2 | n/a | |||||||||||
| Location (UCSC) | Chr 11: 119.98 – 120.06 Mb |
n/a | |||||||||||
| PubMed search | [1] | n/a | |||||||||||
Tripartite motif-containing protein 29 is a protein that in humans is encoded by the TRIM29 gene.[1][2]
The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype.[2]
Interactions [link]
TRIM29 has been shown to interact with TRIM23[1] and GCC1.[3]
References [link]
- ^ a b Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J 20 (9): 2140–51. DOI:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125245.
- ^ a b "Entrez Gene: TRIM29 tripartite motif-containing 29". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23650.
- ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514.
Further reading [link]
- Kapp LN, Painter RB, Yu LC et al. (1992). "Cloning of a candidate gene for ataxia-telangiectasia group D". Am. J. Hum. Genet. 51 (1): 45–54. PMC 1682873. PMID 1609804. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1682873.
- Hosoi Y, Kapp LN (1995). "Expression of a candidate ataxia-telangiectasia group D gene in cultured fibroblast cell lines and human tissues". Int. J. Radiat. Biol. 66 (6 Suppl): S71–6. DOI:10.1080/09553009414551891. PMID 7530755.
- Brzoska PM, Chen H, Zhu Y et al. (1995). "The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7824–8. DOI:10.1073/pnas.92.17.7824. PMC 41238. PMID 7644499. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=41238.
- Murnane JP, Zhu Y, Young BR, Christman MF (1995). "Expression of the candidate A-T gene ATDC is not detectable in a human cell line with a normal response to ionizing radiation". Int. J. Radiat. Biol. 66 (6 Suppl): S77–84. DOI:10.1080/09553009414551901. PMID 7836856.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. DOI:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Leonhardt EA, Kapp LN, Young BR, Murnane JP (1994). "Nucleotide sequence analysis of a candidate gene for ataxia-telangiectasia group D (ATDC)". Genomics 19 (1): 130–6. DOI:10.1006/geno.1994.1022. PMID 8188213.
- Richard CW, Cox DR, Kapp L et al. (1993). "A radiation hybrid map of human chromosome 11q22-q23 containing the ataxia-telangiectasia disease locus". Genomics 17 (1): 1–5. DOI:10.1006/geno.1993.1275. PMID 8406440.
- Laderoute KR, Knapp AM, Green CJ et al. (1996). "Expression of the ATDC (ataxia telangiectasia group D-complementing) gene in A431 human squamous carcinoma cells". Int. J. Cancer 66 (6): 772–8. DOI:10.1002/(SICI)1097-0215(19960611)66:6<772::AID-IJC11>3.0.CO;2-5. PMID 8647648.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. DOI:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Tauchi H, Green C, Knapp M et al. (2000). "Altered splicing of the ATDC message in ataxia telangiectasia group D cells results in the absence of a functional protein". Mutagenesis 15 (2): 105–8. DOI:10.1093/mutage/15.2.105. PMID 10719033.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
- Colland F, Jacq X, Trouplin V et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. DOI:10.1101/gr.2334104. PMC 442148. PMID 15231748. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442148.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514.
- Hosoi Y, Kapp LN, Murnane JP et al. (2006). "Suppression of anchorage-independent growth by expression of the ataxia-telangiectasia group D complementing gene, ATDC". Biochem. Biophys. Res. Commun. 348 (2): 728–34. DOI:10.1016/j.bbrc.2006.07.115. PMID 16890201.
- Beausoleil SA, Villén J, Gerber SA et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. DOI:10.1038/nbt1240. PMID 16964243.
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