TPP

TPP may refer to:

Chemistry

Mathematics and computer science

Medicine

Places

The Phoenix Partnership

TPP (The Phoenix Partnership) is a software company based in Horsforth, Leeds. TPP develop and supply clinical software including SystmOne, which currently holds over 30 million patient records in the UK.

Company history

TPP's product, SystmOne, was developed in 1998 as a clinical IT system to link a GP practice and a diabetes service in Bradford, UK. Since then, SystmOne has been developed for use by healthcare professionals in primary, secondary and social care. TPP now has four product sets: SystmOne, SystmOnline, SystmConnect and SystmInsight.

SystmOne

SystmOne is a clinical computer system developed used by healthcare professionals in the UK in primary, secondary and social care. SystmOne is a centralized, centrally-hosted system based on a "one patient, one record" model.

SystmOne is available for a variety of care settings. Modules for GP, prisons, child health, community units and palliative care are currently widely used throughout the NHS. SystmOne is also available for a variety of secondary care settings, including modules for community and acute hospitals, accident and emergency, maternity, mental health and social services.

Tripeptidyl peptidase I

Tripeptidyl-peptidase 1, also known as Lysosomal pepstatin-insensitive protease, is an enzyme that in humans is encoded by the TPP1 gene.

Gene

The human gene TPP1 encodes a member of the sedolisin family of serine proteases. The human gene has 13 Exons and locates at the chromosome band 11p15.

Structure

The human tripeptidyl-peptidase 1 is 61kDa in size and composed of 563 amino acids. An isoform of 34.5kDa and 320 amino acids is generated by alternative splicing and a peptide fragment of 1-243 amino acid is missing.

Function

The protease functions in the lysosome to cleave N-terminal tripeptides from substrates and has weaker endopeptidase activity. It is synthesized as a catalytically inactive enzyme which is activated and autoproteolyzed upon acidification. Interestingly, TPP1 has been found to regulate the length of telomeres. Telomeres are the ends of linear eukaryotic chromosomes and consist of multiple repeats of a short DNA sequence.The mammalian chromosome end is capped by a protein complex known as shelterin that is composed of six proteins: TRF1, TRF2, RAP1, TIN2, POT1 and TPP1.